| Chemical & Physical Properties | |
|---|---|
| CAS Number | 59338-93-1 |
| Catalog No. | 2A-9009108 |
| Chinese Name | 阿立必利 |
| Synonyms | 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide; EINECS 261-710-6; MFCD00867757 |
| Molecular Formula | C16H21N5O2 |
| Molecular Weight | 315.37000 |
| Purity | 98 |
| Density | 1.224 g/cm3 |
| Boiling Point | 597.6ºC at 760 mmHg |
| Melting Point | 3360°C |
| Application | Alisapride is a potent antiemetic drug that acts as a dopamine receptor antagonist. Alisapride is also used for human digestive system diseases [1][3]. |
| HTC | 2933990090 |
| SMILES | COc1cc2n[nH]nc2cc1C(=O)NCC3CCCN3CC=C |
| InChI | InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20) |
| InChI Key | InChIKey=KSEYRUGYKHXGFW-UHFFFAOYSA-N |
| Use of | Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3]. Properties Name N-((1-Allylpyrrolidin-2-yl)methyl)-6-methoxy-1H-benzo[d][1,2,3]triazole-5-carboxamide Synonym More Synonyms Alizapride Biological Activity Description Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Dopamine 2 receptor References [1]. P L Warzee, et al. Manometric study of the activity of alizapride on the motor function of the human sphincter of Oddi. J Clin Pharm Ther. 1988 Aug;13(4):281-4. [2]. Gomez, et al. Macrophage Fcgamma receptors expression is altered by treatment with dopaminergic drugs. Clinical immunology (Orlando, Fla.) vol. 90,3 (1999): 375-87. [3]. Seng, et al. Anti-emetic effect of high-dose metoclopramide vs alizapride--a randomised crossover study. British journal of clinical pharmacology vol. 38,3 (1994): 282-4. Chemical & Physical Properties Molecular Formula C16H21N5O2 Exact Mass 315.17000 PSA 83.14000 LogP 1.67550 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1H-Benzotriazole-5-carboxamide, 6-methoxy-N-((1-(2-propenyl)-2-pyrrolidinyl)methyl)- CAS REGISTRY NUMBER : 59338-93-1 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H21-N5-O2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : DOSE/DURATION : TOXIC EFFECTS : Behavioral - headache Vascular - BP elevation not characterized in autonomic section REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 312,1125,1985 Safety Information WGK Germany 3 HS Code 2933990090 Precursor & DownStream Precursor 0 DownStream 1 CAS#:59338-92-0 6-Methoxy-1H-be... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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