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Adefovir dipivoxil structure, CAS 142340-99-6

Adefovir dipivoxil

CAS Number142340-99-6

Synonyms9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine; BIS POM PMEA; ADEFOVIR PIVOXIL; Adefovir Dipivoxil; 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine; Hepsera; ADEFOVIR DIPVOXIL; Preveon; MFCD00869897; EINECS 200-001-8; ADEFOVIR DIPIVOLIX; Adefovir Dipivoxyl; Adefovir Dipivoxi; Adefovir Dipivoxl

Molecular FormulaC20H32N5O8P

Molecular Weight501.47

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point641.0±65.0 °C at 760 mmHg

Melting Point98-102ºC

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9009061 Purity: ≥98 (HPLC)%
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Quality Control of [ 142340-99-6 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number142340-99-6
Catalog No.2A-9009061
Chinese Name阿德福韦酯
Synonyms9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine; BIS POM PMEA; ADEFOVIR PIVOXIL; Adefovir Dipivoxil; 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine; Hepsera; ADEFOVIR DIPVOXIL; Preveon; MFCD00869897; EINECS 200-001-8; ADEFOVIR DIPIVOLIX; Adefovir Dipivoxyl; Adefovir Dipivoxi; Adefovir Dipivoxl
Molecular FormulaC20H32N5O8P
Molecular Weight501.47
Purity≥98 (HPLC)
Density1.4±0.1 g/cm3
Boiling Point641.0±65.0 °C at 760 mmHg
Melting Point98-102ºC
Appearancepowder
Storage Condition−20°C
ApplicationAdefovir Dipivoxil blocks HBV reverse transcriptase.
PubChem ID329771057
MDL NumberMFCD00869897
SMILESCC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc12)OCOC(=O)C(C)(C)C
InChI1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChI KeyWOZSCQDILHKSGG-UHFFFAOYSA-N
NACRES CodeNA.76
UNSPSC51102829
MSDSmsds/9061_1_142340_99_6.pdf
BioactivityAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Related Catalog Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16. [2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73. [3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38. [4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 641.0±65.0 °C at 760 mmHg Melting Point 98-102ºC Molecular Formula C20H32N5O8P Molecular Weight 501.470 Flash Point 341.5±34.3 °C Exact Mass 501.198853 PSA 176.79000 LogP 2.45 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.569 InChIKey WOZSCQDILHKSGG-UHFFFAOYSA-N SMILES CC(C)(C)C(=O)OCOP(=O)(COCCn1cnc2c(N)ncnc21)OCOC(=O)C(C)(C)C Storage condition −20°C
Use ofAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Properties Articles37 Name Adefovir dipivoxil Synonym More Synonyms Adefovir Dipivoxil Biological Activity Description Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.Target: NRTIs; HBVAdefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Related Catalog Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection References [1]. Marcellin, P., et al., Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003. 348(9): p. 808-16. [2]. Manolakopoulos, S., et al., Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine. Aliment Pharmacol Ther, 2008. 27(3): p. 266-73. [3]. Committee, A.I.S., A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial. HIV Med, 2002. 3(4): p. 229-38. [4]. Fisher, E.J., et al., The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS, 2001. 15(13): p. 1695-700. Chemical & Physical Properties Molecular Formula C20H32N5O8P Exact Mass 501.198853 PSA 176.79000 Index of Refraction 1.569 InChIKey WOZSCQDILHKSGG-UHFFFAOYSA-N
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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