CAS Number77337-73-6
SynonymsCampral; Acamprosate calcium; MFCD00886588; calcium acetylhomotaurinate; Calciumbis[3-(acetylamino)propan-1-sulfonat]; CA-Aota; Alcomed; 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt (2:1); Sobriol; 1-Propanesulfonic acid, 3-(acetylamino)-, calcium salt (2:1); Calcium bis(3-acetamido-1-propanesulfonate); Calcium Bisacetyl Homotaurine; bis[3-(acétylamino)propane-1-sulfonate] de calcium; Aotal; calcium acetyl homotaurinate; calcium bis[3-(acetylamino)propane-1-sulfonate]; calcium,3-acetamidopropane-1-sulfonate; EINECS 278-665-3; Calcium bis(3-acetamidopropane-1-sulfonate); Acamprosate (calcium)
Molecular FormulaC5H10NO4S.1/2Ca
Molecular Weight200.24
Purity≥98 (HPLC)%
Melting Point>300ºC
Appearancepowder
EINECS278-665-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77337-73-6 |
| Catalog No. | 2A-9009028 |
| Chinese Name | 阿坎酸钙 |
| Synonyms | Campral; Acamprosate calcium; MFCD00886588; calcium acetylhomotaurinate; Calciumbis[3-(acetylamino)propan-1-sulfonat]; CA-Aota; Alcomed; 3-(Acetylamino)-1-propanesulfonic Acid Calcium Salt (2:1); Sobriol; 1-Propanesulfonic acid, 3-(acetylamino)-, calcium salt (2:1); Calcium bis(3-acetamido-1-propanesulfonate); Calcium Bisacetyl Homotaurine; bis[3-(acétylamino)propane-1-sulfonate] de calcium; Aotal; calcium acetyl homotaurinate; calcium bis[3-(acetylamino)propane-1-sulfonate]; calcium,3-acetamidopropane-1-sulfonate; EINECS 278-665-3; Calcium bis(3-acetamidopropane-1-sulfonate); Acamprosate (calcium) |
| Molecular Formula | C5H10NO4S.1/2Ca |
| Molecular Weight | 200.24 |
| Purity | ≥98 (HPLC) |
| Melting Point | >300ºC |
| Appearance | powder |
| Water Solubility | Water solubility: completely dissolved |
| Storage Condition | Room temp |
| Application | Acamprosate calcium (Campral EC) is a GABA receptor agonist and glutamatergic system modulator. |
| EINECS | 278-665-3 |
| HTC | 2924199090 |
| PubChem ID | 329770909 |
| MDL Number | MFCD00886588 |
| SMILES | CC(=O)NCCCS(=O)(=O)O[Ca]OS(=O)(=O)CCCNC(C)=O |
| InChI | 1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2 |
| InChI Key | BUVGWDNTAWHSKI-UHFFFAOYSA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9028_1_77337_73_6.pdf |
| Bioactivity | Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.).Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x. [2]. Witkiewitz K, Saville K, Hamreus K.Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.Ther Clin Risk Manag. 2012;8:45-53. [3]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15. [4]. Palucha-Poniewiera A, Pilc A.Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6. [5]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology. 2012 Jun;62(8):2480-8. Chemical & Physical Properties Melting Point >300ºC Molecular Formula C5H10NO4S.1/2Ca Molecular Weight 200.24 PSA 189.36000 LogP 1.05900 InChIKey BUVGWDNTAWHSKI-UHFFFAOYSA-L SMILES CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2] Storage condition Room temp |
| Use of | Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol. Properties Name acamprosate calcium Synonym More Synonyms Acamprosate calcium Biological Activity Description Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.IC50 value:Target: GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [2]. Witkiewitz K, Saville K, Hamreus K.Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility.Ther Clin Risk Manag. 2012;8:45-53. [3]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15. [4]. Palucha-Poniewiera A, Pilc A.Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test.Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6. [5]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology. 2012 Jun;62(8):2480-8. Chemical & Physical Properties PSA 189.36000 LogP 1.05900 InChIKey BUVGWDNTAWHSKI-UHFFFAOYSA-L SMILES CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2] Storage condition Room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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