CAS Number480-44-4
SynonymsLinarigenin; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; Acacetin; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 5,7-Dihydroxy-4'-methoxyflavone; Apigenin-4'-methyl Ether; 4'-O-Methylapigenin; Buddleoflavonol; MFCD00016936; 4'-Methoxyapigenin; Apigenin 4'-methyl ether; EINECS 207-552-3
Molecular FormulaC16H12O5
Molecular Weight284.26
Purity≥97.0 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point518.6±50.0 °C at 760 mmHg
Melting Point260-265 °C (lit.)
Appearancepowder or crystals
EINECS207-552-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 480-44-4 |
| Catalog No. | 2A-9009027 |
| Chinese Name | 金合欢素； 刺槐素 |
| Synonyms | Linarigenin; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; Acacetin; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 5,7-Dihydroxy-4'-methoxyflavone; Apigenin-4'-methyl Ether; 4'-O-Methylapigenin; Buddleoflavonol; MFCD00016936; 4'-Methoxyapigenin; Apigenin 4'-methyl ether; EINECS 207-552-3 |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Purity | ≥97.0 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 518.6±50.0 °C at 760 mmHg |
| Melting Point | 260-265 °C (lit.) |
| Appearance | powder or crystals |
| Storage Condition | Store sealed at 2-8°C, placed in a ventilated, dry |
| Application | Acacetin is an important flavonoid compound in treatment. It has antioxidant, anti-inflammatory and anti-cancer effects. |
| EINECS | 207-552-3 |
| HTC | 2914509090 |
| PubChem ID | 329746990 |
| MDL Number | MFCD00016936 |
| SMILES | COc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2 |
| InChI | 1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3 |
| InChI Key | DANYIYRPLHHOCZ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 277879 |
| NACRES Code | NA.47 |
| eCl@ss | 32150233 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9027_1_480_44_4.pdf |
| Bioactivity | 1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Natural Products >> Flavonoids Research Areas >> Others References [1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 518.6±50.0 °C at 760 mmHg Melting Point 260-265 °C(lit.) Molecular Formula C16H12O5 Molecular Weight 284.263 Flash Point 198.3±23.6 °C Exact Mass 284.068481 PSA 79.90000 LogP 3.15 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.669 Storage condition 2-8°C |
| Use of | 1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration Properties Articles33 Name 5,7-dihydroxy-4'-methoxyflavone Synonym More Synonyms Acacetin Biological Activity Description 1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Natural Products >> Flavonoids Research Areas >> Others References [1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74. Chemical & Physical Properties Molecular Formula C16H12O5 Exact Mass 284.068481 PSA 79.90000 Index of Refraction 1.669 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Botanical Reference Standards | ||
|---|---|---|
| (-)-Fisetinidol | 490-49-3 | 2A-9008922 |
| 3'-Methoxypuerarin | 2A-300067 | 2A-9008984 |
| 6-Hydroxyluteolin-7-O-sambubioside | 2A-300091 | 2A-9009008 |
| 6-Shogaol | 555-66-8 | 2A-9009010 |
| 8-Gingerol | 23513-08-8 | 2A-9009018 |
| Actein | 18642-44-9 | 2A-9009058 |
| Agnuside | 11027-63-7 | 2A-9009080 |
| Aloenin | 38412-46-3 | 2A-9009120 |
| Panax Ginseng extract | 50647-08-0 | 2A-9009147 |
| Andrographolide | 5508-58-7 | 2A-9009198 |
| Browse all Botanical Reference Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS