CAS Number19685-09-7
Synonyms10-Hydroxycamptothecin; Hydroxycamptothecine; 10-Hydroxy camptothecin; 10-OH-camptothecin; 10-hydroxy-CPT; Camptothecin,hydroxy; MFCD00189425; 10-Hydroxycamptochecin; Camptothecin, 10-hydroxy; 10-hydroxy-Camptothecin; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Hydroxycamptothecin; 10-hydroxycamptothecine; HCPT; (S)-10-Hydroxycamptothecin
Molecular FormulaC20H16O5N2
Molecular Weight364.36
Purity98%
Density1.6±0.1 g/cm3
Boiling Point820.7±65.0 °C at 760 mmHg
Melting Point265-270°C
AppearanceSolid;White to Yellow to Orange powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19685-09-7 |
| Catalog No. | 2A-9008953 |
| Chinese Name | (S)-10-羟基喜树碱 |
| Synonyms | 10-Hydroxycamptothecin; Hydroxycamptothecine; 10-Hydroxy camptothecin; 10-OH-camptothecin; 10-hydroxy-CPT; Camptothecin,hydroxy; MFCD00189425; 10-Hydroxycamptochecin; Camptothecin, 10-hydroxy; 10-hydroxy-Camptothecin; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Hydroxycamptothecin; 10-hydroxycamptothecine; HCPT; (S)-10-Hydroxycamptothecin |
| Molecular Formula | C20H16O5N2 |
| Molecular Weight | 364.36 |
| Purity | 98 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 820.7±65.0 °C at 760 mmHg |
| Melting Point | 265-270°C |
| Appearance | Solid;White to Yellow to Orange powder to crystal |
| Storage Condition | -20°C Freezer |
| Application | (S)-10-Hydroxycamptothecin is an effective agent in the clinical treatment of liver cancer. |
| HTC | 2934999090 |
| MDL Number | MFCD02093100 |
| SMILES | CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3cc(O)ccc3nc2-1 |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
| InChI Key | HAWSQZCWOQZXHI-FQEVSTJZSA-N |
| MSDS | msds/8953_1_19685_09_7.pdf |
| Use of | Properties Name 10-Hydroxycamptothecin Synonym More Synonyms (S)-10-Hydroxycamptothecin Biological Activity Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Cancer References Chemical & Physical Properties Molecular Formula C20H16N2O5 Exact Mass 364.105927 PSA 101.65000 Index of Refraction 1.777 InChIKey HAWSQZCWOQZXHI-FQEVSTJZSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : 19685-09-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H16-N2-O5.H2-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : REFERENCE : YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 21,492,1986 Safety Information RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route Campathecin (S)-10-Hydroxyc... 19685-09-7 Literature: Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869 (4S)-4-Ethyl-4-... 19685-10-0 (S)-10-Hydroxyc... 19685-09-7 Literature: Josien, Hubert; Ko, Sung-Bo; Bom, David; Curran, Dennis P. Chemistry - A European Journal, 1998 , vol. 4, # 1 p. 67 - 83 Campathecin (S)-10-Hydroxyc... 19685-09-7 19685-11-1 Literature: US6660861 B1, ; Page column 4, 5 ; Precursor & DownStream Precursor 7 CAS#:7689-03-4 Campathecin CAS#:19685-10-0 (4S)-4-Ethyl-4-... CAS#:870527-52-9 1,2,6,7-tetrahy... CAS#:123948-88-9 (S)-10-((Dimeth... DownStream 7 CAS#:91421-42-0 CAS#:91421-43-1 9-Aminocamptothecin CAS#:86639-52-3 7-Ethyl-10-hydr... CAS#:19685-10-0 (4S)-4-Ethyl-4-... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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