CAS Number34391-04-3
Synonyms(-)-Albuterol; (R)-albuterol; R-Albuterol; Levosalbutamol; (a1R)-a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol; (l)-albuterol; (R)-a1-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol; (-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol; (R)-salbutamol; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol; R-Salbutamol; UNII-EDN2NBH5SS; (-)-Salbutamol; Levalbuterol; Albuterol; MFCD00869868; Salbutamol
Molecular FormulaC13H21NO3
Molecular Weight239.311
Purity98%
Density1.2±0.1 g/cm3
Boiling Point433.5±40.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34391-04-3 |
| Catalog No. | 2A-9008937 |
| Chinese Name | 左旋沙丁胺醇 |
| Synonyms | (-)-Albuterol; (R)-albuterol; R-Albuterol; Levosalbutamol; (a1R)-a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol; (l)-albuterol; (R)-a1-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol; (-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol; (R)-salbutamol; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol; R-Salbutamol; UNII-EDN2NBH5SS; (-)-Salbutamol; Levalbuterol; Albuterol; MFCD00869868; Salbutamol |
| Molecular Formula | C13H21NO3 |
| Molecular Weight | 239.311 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 433.5±40.0 °C at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active R-enantiomer of salbutamol. Levalbuterol is a more potent bronchodilator agent than salbuta |
| HTC | 2922509090 |
| SMILES | CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 |
| InChI | InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/m0/s1 |
| InChI Key | NDAUXUAQIAJITI-LBPRGKRZSA-N |
| Use of | Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. Properties Name (R)-salbutamol Synonym More Synonyms Levalbuterol Biological Activity Description Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology References [1]. Randall MJ, et al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells.Front Endocrinol (Lausanne). 2015 Jan 12;5:236. [2]. Ferrada MA, et al. (R)-albuterol decreases immune responses: role of activated T cells.Respir Res. 2008 Jan 14;9:3. Chemical & Physical Properties Molecular Formula C13H21NO3 Exact Mass 239.152145 PSA 72.72000 Index of Refraction 1.566 InChIKey NDAUXUAQIAJITI-LBPRGKRZSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,3-Benzenedimethanol, alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (-)- CAS REGISTRY NUMBER : 34391-04-3 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C13-H21-N-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Endocrine - hypoglycemia Endocrine - changes in spleen weight REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,106,1996 Safety Information Hazard Codes Xn: Harmful; Risk Phrases R22 Safety Phrases S36 HS Code 2922509090 Synthetic Route Total: 1 Page (R)-α1-[[(1,1-d... CAS#:348135-26-2 Levalbuterol CAS#:34391-04-3 CAS#:67-56-1 (R)-α1-[[(1,1-d... CAS#:348135-26-2 Salbutamol EP i... CAS#:870076-72-5 4-[2-(tert-buty... CAS#:18910-70-8 (-)-(R)-2-(tert... CAS#:238762-31-7 Levalbuterol CAS#:34391-04-3 Literature: Fine Chemical Corporation Limited Patent: US6365756 B1, 2002 ; Location in patent: Example 13 ; Precursor & DownStream Precursor 3 CAS#:348135-26-2 (R)-α1-[[(1,1-d... CAS#:67-56-1 CAS#:238762-31-7 (-)-(R)-2-(tert... DownStream 0 |
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