CAS Number6998-60-3
SynonymsRIFAMYCIN SV; rifamycin-S; O4-(tripropylhydrazinocarbonyl-methyl)-rifamycin; Rifamycin,4-O-(2-oxo-2-(tripropylhydrazino)ethyl); rifamycin-B tripropylhydrazide; Rifamycin-B-tripropyl-hydrazid
Molecular FormulaC37H47NO12
Molecular Weight753.79
Purity98.00%
Melting Point300° (dec 140°)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6998-60-3 |
| Catalog No. | 2A-9008727 |
| Chinese Name | 利福霉素 |
| Synonyms | RIFAMYCIN SV; rifamycin-S; O4-(tripropylhydrazinocarbonyl-methyl)-rifamycin; Rifamycin,4-O-(2-oxo-2-(tripropylhydrazino)ethyl); rifamycin-B tripropylhydrazide; Rifamycin-B-tripropyl-hydrazid |
| Molecular Formula | C37H47NO12 |
| Molecular Weight | 753.79 |
| Purity | 98.00 |
| Melting Point | 300° (dec 140°) |
| Storage Condition | -20°C |
| Application | Rifamycin (Rifamycin SV) belongs to the ansamycin antibiotic family and was isolated from the fermentation of Aspergillus mediterranea or its mutants. Rifamycin has broad antibiotic activity against G |
| HTC | 2941903000 |
| MDL Number | MFCD01683928 |
| SMILES | N1C2=CC5(OCC(=O)O5)c3c4c(c(c(c3C2=O)O)C)OC(O\C=C/C(C(C(C(C(C(C(C(\C=C/C=C(\C1=O)/C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C |
| InChI | 1S/C39H47NO14/c1-17-11-10-12-18(2)37(48)40-24-15-39(51-16-26(42)53-39)29-27(33(24)46)32(45)22(6)35-28(29)36(47)38(8,54-35)50-14-13-25(49-9)19(3)34(52-23(7)41)21(5)31(44)20(4)30(17)43/h10-15,17,19-21,25,30-31,34,43-45H,16H2,1-9H3,(H,40,48)/b11-10-,14-13-,1 |
| InChI Key | RAFHKEAPVIWLJC-IQDWRYOJSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 12352200 |
| MSDS | msds/8727_1_6998_60_3.pdf |
| Use of | Rifamycin (Rifamycin SV) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria[1]. Properties Name rifamycin SV Synonym More Synonyms Rifamycin Biological Activity Description Rifamycin (Rifamycin SV) belongs to the family of ansamycin antibiotics and has been isolated from the fermentation of A. mediterranei or its mutants. Rifamycin displays a broad spectrum of antibiotic activity against Gram-positive and, to a lesser extent, Gram-negative bacteria[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial References [1]. Floss HG, et al. Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev. 2005 Feb;105(2):621-32. Chemical & Physical Properties Molecular Formula C37H47NO12 Exact Mass 697.31000 PSA 201.31000 LogP 4.89210 InChIKey HJYYPODYNSCCOU-PTWHBISLSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20 ,22-heptamethyl-, 21-acetate CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C37-H47-N-O12 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ GQ IQ J1 M1 QO1 R1 SOV1 T1 UQ V HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5800 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 2 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - mouse Mammary gland DOSE/DURATION : 6300 nmol/L/24H (Continuous) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 5,141,1980 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,951,1965 Safety Information HS Code 2941903000 |
| Transport Info | Product Name: Rifamycin |
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