CAS Number58-33-3
Synonyms10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, hydrochloride (1:1); 10-(2-Dimethylamino-2-methylethyl)phenothiazine Hydrochloride; 10H-phenothiazine-10-ethanamine, N,N,a-trimethyl-, hydrochloride (1:1); N,N-diméthyl-1-(10H-phénothiazin-10-yl)propan-2-amine chlorhydrate; Genphen; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-aminhydrochlorid; Phenothiazine, 10-[2-(dimethylamino)-propyl]-, hydrochloride; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine hydrochloride (1:1); UNII:R61ZEH7I1I; EINECS 200-375-2; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride (1:1); Thiergan; MFCD00012652; N,N,a-Trimethyl-10H-phenothiazine-10-ethanamine Monohydrochloride; (±)-Promethazine Hydrochloride; N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine Monohydrochloride; Phenothiazin
Molecular FormulaC17H21ClN2S
Molecular Weight320.88
Purity98%
Density1.131 g/cm3
Boiling Point403.7ºC at 760 mmHg
Melting Point230-232°C
Appearancepowder
EINECS200-375-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 58-33-3 |
| Catalog No. | 2A-9008696 |
| Chinese Name | 盐酸异丙嗪 |
| Synonyms | 10H-Phenothiazine-10-ethanamine, N,N,α-trimethyl-, hydrochloride (1:1); 10-(2-Dimethylamino-2-methylethyl)phenothiazine Hydrochloride; 10H-phenothiazine-10-ethanamine, N,N,a-trimethyl-, hydrochloride (1:1); N,N-diméthyl-1-(10H-phénothiazin-10-yl)propan-2-amine chlorhydrate; Genphen; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-aminhydrochlorid; Phenothiazine, 10-[2-(dimethylamino)-propyl]-, hydrochloride; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine hydrochloride (1:1); UNII:R61ZEH7I1I; EINECS 200-375-2; N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride (1:1); Thiergan; MFCD00012652; N,N,a-Trimethyl-10H-phenothiazine-10-ethanamine Monohydrochloride; (±)-Promethazine Hydrochloride; N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine Monohydrochloride; Phenothiazin |
| Molecular Formula | C17H21ClN2S |
| Molecular Weight | 320.88 |
| Purity | 98 |
| Density | 1.131 g/cm3 |
| Boiling Point | 403.7ºC at 760 mmHg |
| Melting Point | 230-232°C |
| Appearance | powder |
| Water Solubility | Water solubility: completely soluble; easily solub |
| Storage Condition | Refrigerator |
| Packaging | III |
| Application | Promethazine hydrochloride (NSC-231688) is a first-generation antihistamine drug, a potent H1 receptor antagonist and a mAChR antagonist. It also has certain affinity for 5-HT2A, 5-HT2C, D2 and _alpha |
| EINECS | 200-375-2 |
| HTC | 2933699090 |
| UN(IATA) | UN 2811 |
| PubChem ID | 24277802 |
| MDL Number | MFCD00012652 |
| SMILES | Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C |
| InChI | 1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H |
| InChI Key | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4166397 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R22;R36/37/38 |
| Safety Description | S26;S36 |
| MSDS | msds/8696_1_58_33_3.pdf |
| Bioactivity | Promethazine Hcl(NSC-231688) is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [2]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. [3]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [4]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. Chemical & Physical Properties Density 1.131 g/cm3 Boiling Point 403.7ºC at 760 mmHg Melting Point 230-232°C Molecular Formula C17H21ClN2S Molecular Weight 320.880 Flash Point 198ºC Exact Mass 320.111389 PSA 31.78000 LogP 5.10640 InChIKey XXPDBLUZJRXNNZ-UHFFFAOYSA-N SMILES CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl Storage condition Refrigerator |
| Use of | Properties Articles14 Name promethazine hydrochloride Synonym More Synonyms promethazine hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease References [1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505. [3]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9. [4]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8. Chemical & Physical Properties Exact Mass 320.111389 PSA 31.78000 LogP 5.10640 InChIKey XXPDBLUZJRXNNZ-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3077 International Maritime Transport Danger Regulations: 3077 International Air Transport Danger Regulations: 3077 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (10-(2-Dimethylamino- 2-methylethyl)phenothiazine hydrochloride) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (10-(2-Dimethylamino- 2-methylethyl)phenothiazine hydrochloride) International air transport hazard regulations: Environmentally hazardous substance, solid, n.o.s. (10-(2-Dimethylamino-2- methylethyl)phenothiazine hydrochloride) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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