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Pregnenolone structure, CAS 145-13-1

Pregnenolone

CAS Number145-13-1

SynonymsEINECS 205-647-4; prenolon; ZK-5553; MFCD00003628; prenenolone; Pregnelone; Pregnenlolone; 3-Hydroxypregn-5-en-20-one; Pregnenolone; 3β-Hydroxy-5-pregnen-20-one; 5-Pregnen-3β-ol-20-one; pregnolon; Progeserone

Molecular FormulaC21H32O2

Molecular Weight316.48

Purity≥98%

Density1.1±0.1 g/cm3

Boiling Point443.3±45.0 °C at 760 mmHg

Melting Point188-190 °C

Flash Point

Appearancepowder

EINECS205-647-4

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9008693 Purity: ≥98%
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Quality Control of [ 145-13-1 ] Purity: ≥98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number145-13-1
Catalog No.2A-9008693
Chinese Name孕烯醇酮
SynonymsEINECS 205-647-4; prenolon; ZK-5553; MFCD00003628; prenenolone; Pregnelone; Pregnenlolone; 3-Hydroxypregn-5-en-20-one; Pregnenolone; 3β-Hydroxy-5-pregnen-20-one; 5-Pregnen-3β-ol-20-one; pregnolon; Progeserone
Molecular FormulaC21H32O2
Molecular Weight316.48
Purity≥98
Density1.1±0.1 g/cm3
Boiling Point443.3±45.0 °C at 760 mmHg
Melting Point188-190 °C
Appearancepowder
Water SolubilityWater solubility: Practically insoluble; soluble i
Storage ConditionStore in a dry and cool place.
PackagingFoil bag
ApplicationPregnenolone is a specific inhibitor of the cannabinoid CB1 receptor.
EINECS205-647-4
HTC2937290090
PubChem ID24899008
MDL NumberMFCD00003628
SMILES[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
InChI1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChI KeyORNBQBCIOKFOEO-QGVNFLHTSA-N
Beilstein/REAXYS2059026
NACRES CodeNA.77
UNSPSC12352211
Safety DescriptionS24/25
MSDSmsds/8693_2_145_13_1.pdf
BioactivityPregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids Target CB1 Receptor Human Endogenous Metabolite In Vitro The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1]. In Vivo Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. Animal Admin Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1]. References [1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 443.3±45.0 °C at 760 mmHg Melting Point 188-190 °C Molecular Formula C21H32O2 Molecular Weight 316.478 Flash Point 188.9±21.3 °C Exact Mass 316.240234 PSA 37.30000 LogP 4.52 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.550 InChIKey ORNBQBCIOKFOEO-UHFFFAOYSA-N SMILES CC(=O)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C Storage condition 2~8℃
Use ofPregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). Properties Articles92 Name pregnenolone Synonym More Synonyms Pregnenolone Biological Activity Description Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC). Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Neurological Disease Natural Products >> Steroids CB1 Receptor Human Endogenous Metabolite References [1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. Chemical & Physical Properties Molecular Formula C21H32O2 Exact Mass 316.240234 PSA 37.30000 Index of Refraction 1.550 InChIKey ORNBQBCIOKFOEO-UHFFFAOYSA-N Storage condition 2~8℃
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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