CAS Number64-65-3
Synonyms3-ethyl-3-methylglutarimide; EINECS 200-588-0; 4-Ethyl-4-methyl-2,6-piperidinedione; Bemegrid; Ahypnon; 4-ethyl-4-methylglutarimide; 4-Ethyl-4-methylpiperidine-2,6-dione; Antibarbi; 3-ethyl-3-methylgluarimide; Methetharimide; bemegride; 4-ethyl-4-methyl-piperidine-2,6-dione; MFCD00006673; Zentraleptin; Agipnon; b,b-Methylethylglutarimide; Megimide
Molecular FormulaC8H13O2N1
Molecular Weight155.2
Density1.0±0.1 g/cm3
Boiling Point282.0±9.0 °C at 760 mmHg
Melting Point126-127 °C(lit.)
Appearancepowder | white
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64-65-3 |
| Catalog No. | 2A-9083943 |
| Chinese Name | 贝美格 |
| Synonyms | 3-ethyl-3-methylglutarimide; EINECS 200-588-0; 4-Ethyl-4-methyl-2,6-piperidinedione; Bemegrid; Ahypnon; 4-ethyl-4-methylglutarimide; 4-Ethyl-4-methylpiperidine-2,6-dione; Antibarbi; 3-ethyl-3-methylgluarimide; Methetharimide; bemegride; 4-ethyl-4-methyl-piperidine-2,6-dione; MFCD00006673; Zentraleptin; Agipnon; b,b-Methylethylglutarimide; Megimide |
| Molecular Formula | C8H13O2N1 |
| Molecular Weight | 155.2 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 282.0±9.0 °C at 760 mmHg |
| Melting Point | 126-127 °C(lit.) |
| Appearance | powder | white |
| Water Solubility | Water solubility: soluble; soluble in: methanol, a |
| Storage Condition | This product should be sealed and stored in a cool |
| Packaging | II |
| Application | Bemegride is a central nervous system stimulant and antidote for barbiturate intoxication. |
| HTC | 2925190090 |
| MDL Number | MFCD00006673 |
| SMILES | CCC1(C)CC(=O)NC(=O)C1 |
| InChI | InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11) |
| InChI Key | ORRZGUBHBVWWOP-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/83943_1_64_65_3.pdf |
| Bioactivity | Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2] Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Mistry DK, et al. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.Exp Physiol, 1990, 75(2),199-209. [2]. Arblaster CI, et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan, 41(1), 3-22. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 282.0±9.0 °C at 760 mmHg Melting Point 126-127 °C(lit.) Molecular Formula C8H13NO2 Molecular Weight 155.194 Flash Point 125.8±18.9 °C Exact Mass 155.094635 PSA 46.17000 LogP 1.52 Appearance of Characters powder | white Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.449 InChIKey ORRZGUBHBVWWOP-UHFFFAOYSA-N SMILES CCC1(C)CC(=O)NC(=O)C1 Storage condition −20°C |
| Use of | Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2] Properties Name 4-ethyl-4-methylpiperidine-2,6-dione Synonym More Synonyms Bemegride Biological Activity Description Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.target: GABAA receptor Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. [2] Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Mistry DK, et al. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.Exp Physiol, 1990, 75(2),199-209. [2]. Arblaster CI, et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan, 41(1), 3-22. Chemical & Physical Properties Molecular Formula C8H13NO2 Exact Mass 155.094635 PSA 46.17000 Appearance of Characters powder | white Index of Refraction 1.449 InChIKey ORRZGUBHBVWWOP-UHFFFAOYSA-N SMILES CCC1(C)CC(=O)NC(=O)C1 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: II |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Potassium4-fluorophenyltrifluoroborate | 192863-35-7 | 2A-9083934 |
| 4-Bromophenacyltriflate | 93128-04-2 | 2A-9083936 |
| 3-(4-Morpholino)propiophenonehydrochloride | 1020-16-2 | 2A-9083937 |
| 3,4-(Methylenedioxy)propiophenone | 28281-49-4 | 2A-9083939 |
| 3-Chloropropyl2-thienylketone | 43076-59-1 | 2A-9083942 |
| 2-(1,1,2,2-Tetrafluoroethoxy)naphthalene | 2796-08-9 | 2A-9083946 |
| 5-Dimethylaminonaphthalene-1-sulfonylfluoride | 34523-28-9 | 2A-9083948 |
| Alpha-hydronyheptafluoronaphthalene | 5386-30-1 | 2A-9083951 |
| 4,5-Dimethyl-2-furoicacidethylester | 119155-04-3 | 2A-9083952 |
| Heptafluoro-2-naphthol | 727-49-1 | 2A-9083953 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS