CAS Number53-36-1
Synonyms6-METHYLPREDNISOLONE ACETATE; (6α,11β)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate; Methylprednisolone acetate; 21-Acetoxy-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione; (6a,11b)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; 6a-Methylprednisolone 21-Acetate; Depo-methylprednisolone; MFCD00144786; EINECS 200-171-3; 6α-Methyl Prednisolone 21-Acetate; 6α-Methylprednisolone 21-acetate; Solsolona
Molecular FormulaC24H32O6
Molecular Weight416.51
Purity97%
Density1.3±0.1 g/cm3
Boiling Point582.5±50.0 °C at 760 mmHg
Melting Point206ºC
Appearanceoff-white solid
EINECS200-171-3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53-36-1 |
| Catalog No. | 2A-9008309 |
| Chinese Name | 甲基泼尼松龙醋酸酯 |
| Synonyms | 6-METHYLPREDNISOLONE ACETATE; (6α,11β)-11,17-Dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate; Methylprednisolone acetate; 21-Acetoxy-11b,17-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione; (6a,11b)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; 6a-Methylprednisolone 21-Acetate; Depo-methylprednisolone; MFCD00144786; EINECS 200-171-3; 6α-Methyl Prednisolone 21-Acetate; 6α-Methylprednisolone 21-acetate; Solsolona |
| Molecular Formula | C24H32O6 |
| Molecular Weight | 416.51 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 582.5±50.0 °C at 760 mmHg |
| Melting Point | 206ºC |
| Appearance | off-white solid |
| Storage Condition | Refrigerator |
| Application | Methylprednisolone acetate is a derivative of prednisolone, a corticosteroid hormone. Methylprednisolone acetate can reduce pain and swelling in the body caused by arthritis and other joint diseases [ |
| EINECS | 200-171-3 |
| SMILES | O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@@]4(C(=CC(=O)C=C4)[C@H](C3)C)C)[C@H](C2)O)CC1)C)C(=O)COC(=O)C |
| InChI | 1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1 |
| InChI Key | PLBHSZGDDKCEHR-LFYFAGGJSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/8309_1_53_36_1.pdf |
| Bioactivity | Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor In Vivo Methylprednisolone acetate (30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days）combines with LPS induces typical features of early AVN of the femoral head[2]. Animal Model: A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide[2] Dosage: 30 mg/kg; 13 mg/kg for 10 consecutive days Administration: 30 mg/kg, intramuscular injection; additional oral doses of 13 mg/kg for 10 consecutive days Result: Lead to chondrocyte degeneration and fibrocartilage expression after 7 weeks. Increased the density of CD31 and VEGF-R2 markers in the femoral head. References [1]. Ha Thi -Ngan Le, et al. A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide. Biomedical Research and Therapy volume 3, Article number: 12 (2016) [2]. Luis M Franco,et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019 Feb 4;216(2):384-406. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 582.5±50.0 °C at 760 mmHg Melting Point 206ºC Molecular Formula C24H32O6 Molecular Weight 416.507 Flash Point 196.5±23.6 °C Exact Mass 416.219879 PSA 100.90000 LogP 3.08 Vapour Pressure 0.0±3.7 mmHg at 25°C Index of Refraction 1.580 InChIKey PLBHSZGDDKCEHR-LFYFAGGJSA-N SMILES CC(=O)OCC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3C(O)CC21C Storage condition Refrigerator |
| Use of | Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo[1][2]. Properties Articles33 Name methylprednisolone acetate Synonym More Synonyms methylprednisolone acetate Biological Activity Description Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo[1][2]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor References [1]. Ha Thi -Ngan Le, et al. A mouse model of osteonecrotic femoral head induced by methylprednisolone and liposaccharide. Biomedical Research and Therapy volume 3, Article number: 12 (2016) [2]. Luis M Franco,et al. Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses. J Exp Med. 2019 Feb 4;216(2):384-406. Chemical & Physical Properties Molecular Formula C24H32O6 Exact Mass 416.219879 PSA 100.90000 Index of Refraction 1.580 InChIKey PLBHSZGDDKCEHR-LFYFAGGJSA-N Storage condition Refrigerator |
| Transport Info | Product Name: 6α-methylprednisolone 21-acetate |
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