CAS Number127-07-1
Synonymshydroxycarbamide; HYDROXYUREA (HYDROXYCARBAMIDE); HYDROXYUREA 127-07-1; Hydroxyurea; Droxia; HYDROXYCARBAMIDE, BP STANDARD; HYDROXYHARNSTOFF; amino-hydroxamic acid; Hydrea; HYDROXYHARNSTOFF(HYDROXYUREA); 1-hydroxyure; hydroxyl urea; Hydroxy urea; HYDROXYCARBAMIDE (HYDROXYUREA); MFCD00007943; Onco-carbide; Oxyurea; N-HYDROXYUREA; EINECS 204-821-7; Litalir; 1-Hydroxyurea; Biosupressin; hydroxyure
Molecular FormulaNH2CONHOH
Molecular Weight76.05
Purity98%
Density1.5±0.1 g/cm3
Boiling Point222.1±23.0 °C at 760 mmHg
Melting Point135-140 °C
Appearancepowder
EINECS204-821-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 127-07-1 |
| Catalog No. | 2A-9008013 |
| Chinese Name | 羟基脲 |
| Synonyms | hydroxycarbamide; HYDROXYUREA (HYDROXYCARBAMIDE); HYDROXYUREA 127-07-1; Hydroxyurea; Droxia; HYDROXYCARBAMIDE, BP STANDARD; HYDROXYHARNSTOFF; amino-hydroxamic acid; Hydrea; HYDROXYHARNSTOFF(HYDROXYUREA); 1-hydroxyure; hydroxyl urea; Hydroxy urea; HYDROXYCARBAMIDE (HYDROXYUREA); MFCD00007943; Onco-carbide; Oxyurea; N-HYDROXYUREA; EINECS 204-821-7; Litalir; 1-Hydroxyurea; Biosupressin; hydroxyure |
| Molecular Formula | NH2CONHOH |
| Molecular Weight | 76.05 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 222.1±23.0 °C at 760 mmHg |
| Melting Point | 135-140 °C |
| Appearance | powder |
| Water Solubility | soluble |
| Storage Condition | storage Store sealed in a cool, dry place. |
| Packaging | III |
| Application | Hydroxyurea is an apoptosis inducer that inhibits DNA synthesis by inhibiting ribonucleotide reductase. |
| EINECS | 204-821-7 |
| HTC | 2928000090 |
| PubChem ID | 24278474 |
| MDL Number | MFCD00007943 |
| SMILES | NC(=O)NO |
| InChI | 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4) |
| InChI Key | VSNHCAURESNICA-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1741548 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/8013_1_127_07_1.pdf |
| Bioactivity | Hydroxyurea is a cell apoptosis inducer that inhibitDNA synthesis through inhibition of ribonucleotide reductase. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer In Vitro Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3]. In Vivo Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4]. Animal Admin Mice: To determine whether hydroxyurea would improve anemia and/or prevent or diminish the development of organ damage in the absence of HbF induction, hydroxyurea, at doses of 25 mg/kg, 50 mg/kg, and 100 mg/kg, or vehicle is administered five days per week to SCD mice[4]. References [1]. Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76(1):24-31. [2]. Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33(12):1486-92. [3]. Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7. [4]. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 222.1±23.0 °C at 760 mmHg Melting Point 135-140 °C Molecular Formula CH4N2O2 Molecular Weight 76.055 Flash Point 88.1±22.6 °C Exact Mass 76.027275 PSA 75.35000 LogP -1.80 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.501 InChIKey VSNHCAURESNICA-UHFFFAOYSA-N SMILES NC(=O)NO Storage condition 2-8°C Water Solubility soluble |
| Use of | Hydroxyurea is a cell apoptosis inducer that inhibitDNA synthesis through inhibition of ribonucleotide reductase. Properties Articles249 Name hydroxyurea Synonym More Synonyms Hydroxyurea Biological Activity Description Hydroxyurea is a cell apoptosis inducer that inhibitDNA synthesis through inhibition of ribonucleotide reductase. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer In Vitro Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3]. References [1]. Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76(1):24-31. [2]. Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33(12):1486-92. [3]. Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7. [4]. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603. Chemical & Physical Properties Molecular Formula CH4N2O2 Exact Mass 76.027275 PSA 75.35000 LogP -1.80 Index of Refraction 1.501 InChIKey VSNHCAURESNICA-UHFFFAOYSA-N SMILES NC(=O)NO Water Solubility soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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