CAS Number244-63-3
SynonymsPyridoindole; CARBAZOLINE; b-carboline; β-carboline; MFCD00004956; betacarboline; Norharmane; 9H-Pyrido[3,4-b]indole; EINECS 205-959-0; Nor Harmane; norhaman; Norharman; beta-carboline; 9H-β-Carboline; 2-Azacarbazole
Molecular FormulaC11H8N2
Molecular Weight168.19
Density1.3±0.1 g/cm3
Boiling Point391.3±15.0 °C at 760 mmHg
Melting Point219-221 ºC
Appearancecrystalline
EINECS205-959-0
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 244-63-3 |
| Catalog No. | 2A-9077458 |
| Chinese Name | 9H-吡啶[3,4-b]吲哚 |
| Synonyms | Pyridoindole; CARBAZOLINE; b-carboline; β-carboline; MFCD00004956; betacarboline; Norharmane; 9H-Pyrido[3,4-b]indole; EINECS 205-959-0; Nor Harmane; norhaman; Norharman; beta-carboline; 9H-β-Carboline; 2-Azacarbazole |
| Molecular Formula | C11H8N2 |
| Molecular Weight | 168.19 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 391.3±15.0 °C at 760 mmHg |
| Melting Point | 219-221 ºC |
| Appearance | crystalline |
| Storage Condition | This product should be sealed and stored at 4℃. |
| Application | Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM. |
| EINECS | 205-959-0 |
| HTC | 2933990090 |
| PubChem ID | 24897776 |
| MDL Number | MFCD00004956 |
| SMILES | c1ccc2c(c1)[nH]c3cnccc23 |
| InChI | 1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H |
| InChI Key | AIFRHYZBTHREPW-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/77458_1_244_63_3.pdf |
| Bioactivity | Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Target MAO-A:3.34 μM (Ki) Human Endogenous Metabolite References [1]. Herraiz T, et al. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006 Jan 18;78(8):795-802. [2]. Lee HW, et al. Potent Selective Inhibition of Monoamine Oxidase A by Alternariol Monomethyl Ether Isolated from Alternaria brassicae. J Microbiol Biotechnol. 2017 Feb 28;27(2):316-320. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 391.3±15.0 °C at 760 mmHg Melting Point 219-221 ºC Molecular Formula C11H8N2 Molecular Weight 168.195 Flash Point 182.1±11.7 °C Exact Mass 168.068741 PSA 28.68000 LogP 2.80 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.785 InChIKey AIFRHYZBTHREPW-UHFFFAOYSA-N SMILES c1ccc2c(c1)[nH]c1cnccc12 Storage condition 2-8°C |
| Use of | Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM[1]. Properties Articles38 Name β-carboline Synonym More Synonyms Norharmane Biological Activity Description Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease MAO-A:3.34 μM (Ki) Human Endogenous Metabolite References [1]. Herraiz T, et al. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006 Jan 18;78(8):795-802. [2]. Lee HW, et al. Potent Selective Inhibition of Monoamine Oxidase A by Alternariol Monomethyl Ether Isolated from Alternaria brassicae. J Microbiol Biotechnol. 2017 Feb 28;27(2):316-320. Chemical & Physical Properties Molecular Formula C11H8N2 Exact Mass 168.068741 PSA 28.68000 Index of Refraction 1.785 InChIKey AIFRHYZBTHREPW-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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