CAS Number148849-67-6
SynonymsIvabradine hydrochloride; AMG 998; Coralan; Procoralan; Corlentor; ivabradine monohydrochloride; Ivabradine hcl; MFCD00929899; UNII-TP19837BZK; Corlanor
Molecular FormulaC27H37O5N2Cl1
Molecular Weight505.05
Boiling Point626.9ºC at 760mmHg
Melting Point193-196?C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 148849-67-6 |
| Catalog No. | 2A-9076753 |
| Chinese Name | 盐酸伊伐布雷定 |
| Synonyms | Ivabradine hydrochloride; AMG 998; Coralan; Procoralan; Corlentor; ivabradine monohydrochloride; Ivabradine hcl; MFCD00929899; UNII-TP19837BZK; Corlanor |
| Molecular Formula | C27H37O5N2Cl1 |
| Molecular Weight | 505.05 |
| Boiling Point | 626.9ºC at 760mmHg |
| Melting Point | 193-196?C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | -20°C Freezer |
| Application | Ivabradine hydrochloride is a novel If inhibitor with an IC50 value of 2.9 μM, used to reduce heart rate. |
| PubChem ID | 10052730 |
| MDL Number | MFCD00929899 |
| SMILES | COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CC1Cc3cc(OC)c(OC)cc31)CC2.Cl |
| InChI | InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 |
| InChI Key | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| MSDS | msds/76753_1_148849_67_6.pdf |
| Bioactivity | Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease In Vivo Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2]. References [1]. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7. [2]. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Res Cardiol, 2011. 106(6): p. 1147-58. Chemical & Physical Properties Boiling Point 626.9ºC at 760mmHg Melting Point 193-196?C Molecular Formula C27H37ClN2O5 Molecular Weight 505.046 Flash Point 332.9ºC Exact Mass 504.239105 PSA 60.47000 LogP 4.04990 Vapour Pressure 1.24E-15mmHg at 25°C InChIKey HLUKNZUABFFNQS-ZMBIFBSDSA-N SMILES COc1cc2c(cc1OC)CC(=O)N(CCCN(C)CC1Cc3cc(OC)c(OC)cc31)CC2.Cl Storage condition -20°C Freezer |
| Use of | Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Properties Name ivabradine hydrochloride Synonym More Synonyms Ivabradine hydrochloride Biological Activity Description Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7. [2]. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Res Cardiol, 2011. 106(6): p. 1147-58. Chemical & Physical Properties Exact Mass 504.239105 PSA 60.47000 LogP 4.04990 InChIKey HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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