CAS Number4205-91-8
Synonyms(2,6-dichlorophenyl)imidazolidin-2-ylidene-amine hydrochloride; ipotensium; catapresan; klophelin; Clonidine hydrochloride; Isoglaucon; N-(2,6-Dichlorophenyl)imidazolidin-2-imine hydrochloride (1:1); dcai; hemiton; Dixarit; MFCD00036705; Clonidine HCl; Clonidine monohydrochloride; capresin; Neuclon; 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine Monohydrochloride; 2,6-dichloro-N-imidazolidin-2-ylideneaniline hydrochloride; clofelin; clonidine hydrochloride salt; Clonistada; Tenso-Timelets; EINECS 224-121-5; 2-(2,6-Dichlorophenylamino)-2-imidazoline Hydrochloride; 2,6-Dichloro-N-(imidazolidin-2-ylidene)aniline hydrochloride (1:1); atensina; DURACLON; haemiton; (2,6-dichloro-phenyl)-imidazolidin-2-ylidene-amine,hydrogen chloride; 2-(2,6-Dichloroanilino)-2-iMidazoline Hydrochloride; Catapres
Molecular FormulaC9H10Cl3N3
Molecular Weight266.55
Purity98%
Boiling Point319.3ºC at760mmHg
Melting Point312 °C
Appearancesolid
EINECS224-121-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4205-91-8 |
| Catalog No. | 2A-9007433 |
| Chinese Name | 盐酸可乐定 |
| Synonyms | (2,6-dichlorophenyl)imidazolidin-2-ylidene-amine hydrochloride; ipotensium; catapresan; klophelin; Clonidine hydrochloride; Isoglaucon; N-(2,6-Dichlorophenyl)imidazolidin-2-imine hydrochloride (1:1); dcai; hemiton; Dixarit; MFCD00036705; Clonidine HCl; Clonidine monohydrochloride; capresin; Neuclon; 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine Monohydrochloride; 2,6-dichloro-N-imidazolidin-2-ylideneaniline hydrochloride; clofelin; clonidine hydrochloride salt; Clonistada; Tenso-Timelets; EINECS 224-121-5; 2-(2,6-Dichlorophenylamino)-2-imidazoline Hydrochloride; 2,6-Dichloro-N-(imidazolidin-2-ylidene)aniline hydrochloride (1:1); atensina; DURACLON; haemiton; (2,6-dichloro-phenyl)-imidazolidin-2-ylidene-amine,hydrogen chloride; 2-(2,6-Dichloroanilino)-2-iMidazoline Hydrochloride; Catapres |
| Molecular Formula | C9H10Cl3N3 |
| Molecular Weight | 266.55 |
| Purity | 98 |
| Boiling Point | 319.3ºC at760mmHg |
| Melting Point | 312 °C |
| Appearance | solid |
| Water Solubility | H2O: 50 mg/mL, clear, colorless |
| Storage Condition | Keep away from light, ventilated and dry, sealed |
| Packaging | III |
| Application | Clonidine hydrochloride is an α2-adrenoceptor agonist and a potent antihypertensive drug. |
| EINECS | 224-121-5 |
| HTC | 2933290090 |
| UN(IATA) | UN 2811 |
| PubChem ID | 24277750 |
| MDL Number | MFCD00036705 |
| SMILES | Cl[H].Clc1cccc(Cl)c1NC2=NCCN2 |
| InChI | 1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H |
| InChI Key | ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4163525 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| Risk Codes | R25;R26 |
| Safety Description | S22;S26;S28;S36/37/39;S45 |
| MSDS | msds/7433_1_4205_91_8.pdf |
| Bioactivity | Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease In Vitro Clonidine (0.01, 0.1 or 1 μM) significantly induces CGRP (α and β) mRNA expression in a dose-dependent manner in endothelial cells. Clonidine treatment (1 μM) for 24 h significantly increases the NO level in endothelial cells. NO pathway modulates CGRP production induced by clonidine[2]. In Vivo Clonidine (50 μg/kg, i.p.) induces a significant decrease in body temperature of rat lasting 3 hr, with the maximum at 1 hr after administration. An intracerebroventricular pretreatment of rats with neutral doses of phentolamine 15 min before clonidine considerably antagonizes the clonidine-induced hypothermia[1]. Clonidine (0.003-0.05 mg/kg, i.p.) potently suppresses dopamine efflux in the prefrontal cortex induced by PCP. Pretreatment with the alpha-2A receptor antagonist (BRL-44408) prevents clonidine from suppressing PCP-induced dopamine overflow in the prefrontal cortex[3]. In DMSO-pretreated SO rats, clonidine (0.6 μg i.c.) has no effect on blood pressure. However, after central adenosine A1R blockade (DPCPX) in SO rats, clonidine significantly (P < 0.05, one-way ANOVA) reduces blood pressure. In contrast, in DMSO-pretreated ABD rats, clonidine (0.6 μg i.c.) causes significant reduction in blood pressure; importantly, central A1R blockade (DPCPX pretreatment) does not influence (P > 0.05, one-way ANOVA) clonidine-evoked reduction in blood pressure in ABD rats. In DPCPX-pretreated SO rats and along with the appearance of the hypotensive response, clonidine causes a significant (P < 0.05) increase in the RVLM pERK1/2 level compared with basal or clonidine treatment in DMSO-pretreated SO rats. In vehicle (DMSO)-pretreated ABD rats, clonidine significantly (P < 0.05) enhances RVLM pERK1/2, and this response is not affected by DPCPX pretreatment[4]. Animal Admin On the day of the experiment, the flow rate is increased to 2 μL/min approximately 2 h before beginning the collection of baseline samples. Dialysates are collected every 20 min; after 4 baseline samples are collected, animals are pretreated with an intra-peritoneal (i.p.) injection of either 0.9% saline (the vehicle), clonidine (0.0033, 0.01 or 0.05 mg/kg) or guanfacine (0.05 or 0.5 mg/kg), before receiving an injection of PCP (2.5 mg/kg, i.p.) 20 min later. In a separate study, BRL (1.0 mg/kg) is administered 20 min prior to clonidine. In addition, for some control experiments, the animals only receive one injection of saline, clonidine (0.01 or 0.05 mg/kg), guanfacine (0.5 mg/kg) or BRL (1.0 mg/kg). References [1]. Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15. [2]. Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52. [3]. Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6. [4]. Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9. Chemical & Physical Properties Boiling Point 319.3ºC at760mmHg Melting Point 312 °C Molecular Formula C9H10Cl3N3 Molecular Weight 266.555 Flash Point 146.9ºC Exact Mass 264.994019 PSA 36.42000 LogP 3.00390 InChIKey ZNIFSRGNXRYGHF-UHFFFAOYSA-N SMILES Cl.Clc1cccc(Cl)c1NC1=NCCN1 Storage condition 2-8°C Water Solubility H2O: 50 mg/mL, clear, colorless |
| Use of | Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent. Properties Articles23 Name Clonidine hydrochloride Synonym More Synonyms Clonidine hydrochloride Biological Activity Description Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease In Vitro Clonidine (0.01, 0.1 or 1 μM) significantly induces CGRP (α and β) mRNA expression in a dose-dependent manner in endothelial cells. Clonidine treatment (1 μM) for 24 h significantly increases the NO level in endothelial cells. NO pathway modulates CGRP production induced by clonidine[2]. References [1]. Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15. [2]. Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52. [3]. Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6. Chemical & Physical Properties Exact Mass 264.994019 PSA 36.42000 LogP 3.00390 InChIKey ZNIFSRGNXRYGHF-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: I |
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