CAS Number618-27-9
Synonyms(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid; cis-4-Hydroxy-L-proline; (4R)-4-Hydroxy-D-proline; cis-4-Hydroxyproline; MFCD00064319; (4S)-4-Hydroxy-L-prolin; cis-4-Hydroxy-D-proline; EINECS 210-542-1
Molecular FormulaC5H9NO3
Molecular Weight131.13
Purity≥98 (TLC)%
Density1.4±0.1 g/cm3
Boiling Point355.2±42.0 °C at 760 mmHg
Melting Point257 °C (dec.) (lit.)
Appearancepowder
EINECS210-542-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 618-27-9 |
| Catalog No. | 2A-9007424 |
| Chinese Name | 顺式-4-羟基-L-脯氨酸 |
| Synonyms | (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid; cis-4-Hydroxy-L-proline; (4R)-4-Hydroxy-D-proline; cis-4-Hydroxyproline; MFCD00064319; (4S)-4-Hydroxy-L-prolin; cis-4-Hydroxy-D-proline; EINECS 210-542-1 |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.13 |
| Purity | ≥98 (TLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 355.2±42.0 °C at 760 mmHg |
| Melting Point | 257 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Sealed packaging in brown glass bottles. Store in |
| Application | cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline inhibits fibroblast growth by preventing the deposition of triple-helical collagen on the c |
| EINECS | 210-542-1 |
| HTC | 2933990090 |
| PubChem ID | 24895470 |
| MDL Number | MFCD00064319 |
| SMILES | O[C@@H]1CN[C@@H](C1)C(O)=O |
| InChI | 1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1 |
| InChI Key | PMMYEEVYMWASQN-IMJSIDKUSA-N |
| Beilstein/REAXYS | 81440 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| Safety Description | S24/25 |
| MSDS | msds/7424_1_618_27_9.pdf |
| Bioactivity | cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4]. Related Catalog Research Areas >> Cancer Research Areas >> Metabolic Disease References [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 355.2±42.0 °C at 760 mmHg Melting Point 257ºC Molecular Formula C5H9NO3 Molecular Weight 131.130 Flash Point 168.6±27.9 °C Exact Mass 131.058243 PSA 69.56000 LogP -1.84 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.540 InChIKey PMMYEEVYMWASQN-IMJSIDKUSA-N SMILES O=C(O)C1CC(O)CN1 |
| Use of | cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4]. Properties Articles25 Name cis-4-hydroxy-L-proline Synonym More Synonyms cis-4-hydroxy-L-proline Biological Activity Description cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4]. Related Catalog Research Areas >> Cancer Research Areas >> Metabolic Disease References [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93. Chemical & Physical Properties Molecular Formula C5H9NO3 Exact Mass 131.058243 PSA 69.56000 LogP -1.84 Index of Refraction 1.540 InChIKey PMMYEEVYMWASQN-IMJSIDKUSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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