CAS Number25122-46-7
SynonymsTemovate; Olux; Clobetasol propionate; clobetasol-17-propionate; Dermoxin; Dermoval; Cloβsol 17-Propionate; CCl 4725; Clobetasol 17-Propionate; EINECS 246-634-3; cgp9555; 21-Chloro-9α-fluoro-11β,17α-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-Propionate; Clobetasol propionate (JAN/USP); Clobetasolpropionate; Clobetasol propionate [USAN:JAN]; Dermovate; clobesol; (11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate; Psorex; MFCD00058499; (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
Molecular FormulaC25H32ClFO5
Molecular Weight466.97
Purity97%
Density1.3±0.1 g/cm3
Boiling Point569.0±50.0 °C at 760 mmHg
Melting Point195.5-197ºC
Appearancepowder
EINECS246-634-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 25122-46-7 |
| Catalog No. | 2A-9007432 |
| Chinese Name | 丙酸氯倍他索 |
| Synonyms | Temovate; Olux; Clobetasol propionate; clobetasol-17-propionate; Dermoxin; Dermoval; Cloβsol 17-Propionate; CCl 4725; Clobetasol 17-Propionate; EINECS 246-634-3; cgp9555; 21-Chloro-9α-fluoro-11β,17α-dihydroxy-16β-methyl-1,4-pregnadiene-3,20-dione 17-Propionate; Clobetasol propionate (JAN/USP); Clobetasolpropionate; Clobetasol propionate [USAN:JAN]; Dermovate; clobesol; (11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propionate; Psorex; MFCD00058499; (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate |
| Molecular Formula | C25H32ClFO5 |
| Molecular Weight | 466.97 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 569.0±50.0 °C at 760 mmHg |
| Melting Point | 195.5-197ºC |
| Appearance | powder |
| Water Solubility | Soluble in: dioxane |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Clobetasol propionate is an anti-inflammatory corticosteroid that can be used to treat various skin diseases. |
| EINECS | 246-634-3 |
| HTC | 2937290090 |
| MDL Number | MFCD00058499 |
| SMILES | CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl |
| InChI | 1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 |
| InChI Key | CBGUOGMQLZIXBE-XGQKBEPLSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Xi |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S36 |
| MSDS | msds/7432_1_25122_46_7.pdf |
| Bioactivity | Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.Target: Glucocorticoid ReceptorClobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules). From Wikipedia. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Clobetasol_propionate Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 569.0±50.0 °C at 760 mmHg Melting Point 195.5-197ºC Molecular Formula C25H32ClFO5 Molecular Weight 466.970 Flash Point 297.9±30.1 °C Exact Mass 466.192230 PSA 80.67000 LogP 3.98 Vapour Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.560 InChIKey CBGUOGMQLZIXBE-XGQKBEPLSA-N SMILES CCC(=O)OC1(C(=O)CCl)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C |
| Use of | Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.Target: Glucocorticoid ReceptorClobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules). From Wikipedia. Properties Articles52 Name clobetasol propionate Synonym More Synonyms Clobetasol propionate Biological Activity Description Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.Target: Glucocorticoid ReceptorClobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus (auto immune skin nodules). From Wikipedia. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Clobetasol_propionate Chemical & Physical Properties Exact Mass 466.192230 PSA 80.67000 Index of Refraction 1.560 InChIKey CBGUOGMQLZIXBE-XGQKBEPLSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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