| Chemical & Physical Properties | |
|---|---|
| CAS Number | 649735-63-7 |
| Catalog No. | 2A-9060221 |
| Chinese Name | 丙氨酸布立尼布 |
| Synonyms | Brivanib L-alanine ester; Brivanib alaninate; cc-420; 1-[[4-[(4--2--1H--5-)]-5-[2,1-F][1,2,4]-6-]]-2-L; BMS-582664; Brivanib (alaninate) |
| Molecular Formula | C22H24O4N5F1 |
| Molecular Weight | 441.46 |
| Density | 1.4±0.1 g/cm3 |
| Storage Condition | -20°C |
| Application | Brivanib alaninate is an ATP-competitive VEGFR2 inhibitor with an IC50 value of 25 nM; it can moderately inhibit VEGFR1 and FGFR1, and its selectivity for VEGFR2 is 240 times higher than that for PDGF |
| HTC | 2933990090 |
| MDL Number | MFCD22577162 |
| SMILES | Cc1cc2c(F)c(Oc3ncnn4cc(OCC(C)OC(=O)C(C)N)c(C)c34)ccc2[nH]1 |
| InChI Key | LTEJRLHKIYCEOX-OCCSQVGLSA-N |
| MSDS | msds/60221_1_649735_63_7.pdf |
| Use of | Brivanib alaninate is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Properties Name [(2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-yl] (2S)-2-aminopropanoate Synonym More Synonyms Brivanib Alaninate (BMS-582664) Biological Activity Description Brivanib alaninate is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer VEGFR2:25 nM (IC50) References [1]. Bhide RS, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem, 2006, 49 (7), 2143-2146. [2]. Huynh H, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res, 2008, 14(19), 6146-6153. [3]. Nakamura I, et al. Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling. PLoS One. 2015 Nov 3;10(11):e0142355. Chemical & Physical Properties Molecular Formula C22H24FN5O4 Exact Mass 441.181244 PSA 116.76000 Index of Refraction 1.648 InChIKey LTEJRLHKIYCEOX-OCCSQVGLSA-N Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page (R)-1-((4-((4-f... CAS#:649736-41-4 Brivanib Alanin... CAS#:649735-63-7 Literature: Cai, Zhen-Wei; Zhang, Yongzheng; Borzilleri, Robert M.; Qian, Ligang; Barbosa, Stephanie; Wei, Donna; Zheng, Xiaoping; Wu, Lawrence; Fan, Junying; Shi, Zhongping; Wautlet, Barri S.; Mortillo, Steve; Jeyaseelan Sr., Robert; Kukral, Daniel W.; Kamath, Amrita; Marathe, Punit; D'Arienzo, Celia; Derbin, George; Barrish, Joel C.; Robl, Jeffrey A.; Hunt, John T.; Lombardo, Louis J.; Fargnoli, Joseph; Bhide, Rajeev S. Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1976 - 1980 Precursor & DownStream Precursor 1 CAS#:649736-41-4 (R)-1-((4-((4-f... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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