| Chemical & Physical Properties | |
|---|---|
| CAS Number | 274693-27-5 |
| Catalog No. | 2A-9056249 |
| Chinese Name | 替卡格雷 |
| Synonyms | Brilinta; Possia; TICARGRELOR; Ticagrelor; AZD 6140; Brilique |
| Molecular Formula | C23H28F2N6O4S |
| Molecular Weight | 522.57 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 777.6±70.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Ticagrelor (AZD6140) is a reversible and orally active P2Y12 receptor antagonist that can be used to treat platelet aggregation. |
| HTC | 2933990090 |
| MDL Number | MFCD09954148 |
| SMILES | FC1=C(F)C=C([C@]2([H])C[C@@]2([H])NC3=NC(SCCC)=NC4=C3N=NN4[C@]5([H])C[C@H](OCCO)[C@@H](O)[C@H]5O)C=C1 |
| InChI | 1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1 |
| InChI Key | OEKWJQXRCDYSHL-FNOIDJSQSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/56249_1_274693_27_5.pdf |
| Use of | Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation. Properties Name ticagrelor Synonym More Synonyms Ticagrelor Biological Activity Description Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation. Related Catalog Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Cardiovascular Disease References [1]. Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128(23):2717-2728. [2]. Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer. 2015 Jan 1;136(1):234-40. [3]. Sugidachi A, et al. A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats. Br J Pharmacol. 2013 May;169(1):82-9. Chemical & Physical Properties Molecular Formula C23H28F2N6O4S Exact Mass 522.186096 PSA 163.74000 Index of Refraction 1.744 InChIKey OEKWJQXRCDYSHL-FNOIDJSQSA-N Safety Information HS Code 2933990090 Synthetic Route 1383715-61-4 Ticagrelor 274693-27-5 Literature: EP2570405 A1, ; Paragraph 0078; 0079 ; (1S,2S,3R,5S)-3... 1354945-69-9 (1R,2S)-2-(3,4-... 1444301-72-7 Ticagrelor 274693-27-5 1427524-43-3 Ticagrelor 274693-27-5 Precursor & DownStream Precursor 3 CAS#:1354945-69-9 (1S,2S,3R,5S)-3... CAS#:274693-26-4 2-[[(3aS,4R,6S,... CAS#:1445580-43-7 (1S,2S,3R,5S)-3... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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