CAS Number231277-92-2
SynonymsLapatinib (2TsOH); GW-2016; Lapatinib [INN]; Tyverb; Lapatinib; Tykerb
Molecular FormulaC29H26ClFN4O4S
Molecular Weight581.06
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point750.7±60.0 °C at 760 mmHg
Melting Point147 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 231277-92-2 |
| Catalog No. | 2A-9055877 |
| Chinese Name | 拉帕替尼 |
| Synonyms | Lapatinib (2TsOH); GW-2016; Lapatinib [INN]; Tyverb; Lapatinib; Tykerb |
| Molecular Formula | C29H26ClFN4O4S |
| Molecular Weight | 581.06 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 750.7±60.0 °C at 760 mmHg |
| Melting Point | 147 °C |
| Appearance | powder |
| Storage Condition | 0-10°C; store in inert gas; avoid air, heat |
| Packaging | II |
| Application | Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.2 and 9.8 nM respectively. |
| HTC | 2934999090 |
| MDL Number | MFCD09264194 |
| SMILES | CS(=O)(CCNCC1=CC=C(C2=CC=C3N=CN=C(C3=C2)NC4=CC=C(C(Cl)=C4)OCC5=CC=CC(F)=C5)O1)=O |
| InChI | 1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) |
| InChI Key | BCFGMOOMADDAQU-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| MSDS | msds/55877_1_231277_92_2.pdf |
| Use of | Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively. Properties Name lapatinib Synonym More Synonyms Lapatinib (GW572016) Biological Activity Description Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Research Areas >> Cancer EGFR:10.2 nM (IC50, Cell Free Assay) ErbB2:9.8 nM (IC50, Cell Free Assay) References [1]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94 [2]. O'Neill F, et al. Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines. Mol Cancer. 2012 Jun 18;11(1):41. [3]. Eryilmaz U, et al. S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS One. 2015 Dec 18;10(12):e0145418. [4]. Ni J, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 Jul;22(7):723-6. Chemical & Physical Properties Exact Mass 580.134705 PSA 114.73000 Index of Refraction 1.645 Safety Information Hazard Codes T,F WGK Germany 3 Packaging Group II Hazard Class 6.1 HS Code 2934999090 Synthetic Route 2-Aminoethyl me... 49773-20-8 5-[4-[3-chloro-... 231278-84-5 Lapatinib (GW57... 231277-92-2 Lapatinib ditos... 388082-78-8 Lapatinib (GW57... 231277-92-2 N-(3-chloro-4-(... 1227853-06-6 Lapatinib (GW57... 231277-92-2 Precursor & DownStream Precursor 10 CAS#:49773-20-8 2-Aminoethyl me... CAS#:231278-84-5 5-[4-[3-chloro-... CAS#:388082-78-8 Lapatinib ditos... CAS#:1227853-06-6 N-(3-chloro-4-(... DownStream 1 CAS#:388082-78-8 Lapatinib ditos... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Tigecycline | 220620-09-7 | 2A-9055748 |
| 17beta-Estradiol-2,4,16,16,17-D5 | 221093-45-4 | 2A-9055760 |
| Vardenafil hydrochloride | 224785-91-5 | 2A-9055817 |
| Atazanavir sulfate | 229975-97-7 | 2A-9055855 |
| Varenicline hydrochloride | 230615-23-3 | 2A-9055866 |
| Prasugrel metabolite | 239466-74-1 | 2A-9055916 |
| Isavuconazole | 241479-67-4 | 2A-9055922 |
| 9,11-Didehydroestriol | 246021-20-5 | 2A-9055951 |
| Varenicline | 249296-44-4 | 2A-9055984 |
| Ticagrelor | 274693-27-5 | 2A-9056249 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS