| Chemical & Physical Properties | |
|---|---|
| CAS Number | 224452-66-8 |
| Catalog No. | 2A-9055814 |
| Chinese Name | 瑞他莫林 |
| Synonyms | Rebapamulin; Altabax; Altargo; MFCD11045316; Retapamulin |
| Molecular Formula | C30H47NO4S |
| Molecular Weight | 517.76 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 594.9±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2~8℃ |
| Application | Retapamulin (SB-275833) is a topical antibiotic that binds to Staphylococcus aureus and E. coli ribosomes with a Kd of 3 nM. |
| HTC | 2933990090 |
| MDL Number | MFCD11045316 |
| SMILES | S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C |
| InChI | 1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1 |
| InChI Key | STZYTFJPGGDRJD-FJJJPKKESA-N |
| NACRES Code | NA.76 |
| UNSPSC | 51284706 |
| MSDS | msds/55814_1_224452_66_8.pdf |
| Use of | Retapamulin(SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.IC50 Value: 3 nM(Kd, E.coli)Target: AntibacterialRetapamulin is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drug in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the brand names Altabax and Altargo. Retapamulin(SB-275833) is useful for Antibiotics. Properties Name Retapamulin Synonym More Synonyms Retapamulin Biological Activity Description Retapamulin(SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.IC50 Value: 3 nM(Kd, E.coli)Target: AntibacterialRetapamulin is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drug in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the brand names Altabax and Altargo. Retapamulin(SB-275833) is useful for Antibiotics. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Others References [1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60. [2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30. [3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8. [4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204. [5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517. Chemical & Physical Properties Molecular Formula C30H47NO4S Exact Mass 517.322571 PSA 92.14000 Index of Refraction 1.571 InChIKey STZYTFJPGGDRJD-RVYJGNDLSA-N Storage condition 2~8℃ Safety Information Hazard Codes Xi HS Code 2933990090 Synthetic Route Total: 1 Page 8-Methyl-8-azab... CAS#:848130-83-6 Pleuromutilin-2... CAS#:60924-38-1 Retapamulin CAS#:224452-66-8 Precursor & DownStream Precursor 2 CAS#:848130-83-6 8-Methyl-8-azab... CAS#:60924-38-1 Pleuromutilin-2... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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