CAS Number212631-79-3
SynonymsCI-1040; 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide CI-1040; 2-((2-Chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Molecular FormulaC17H14ClF2IN2O2
Molecular Weight478.66
Purity≥98 (HPLC)%
Density1.7±0.1 g/cm3
Melting Point166-169ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 212631-79-3 |
| Catalog No. | 2A-9055536 |
| Chinese Name | PD184352 (CI-1040) |
| Synonyms | CI-1040; 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide CI-1040; 2-((2-Chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide |
| Molecular Formula | C17H14ClF2IN2O2 |
| Molecular Weight | 478.66 |
| Purity | ≥98 (HPLC) |
| Density | 1.7±0.1 g/cm3 |
| Melting Point | 166-169ºC |
| Appearance | powder |
| Water Solubility | DMSO: ≥30mg/mL |
| Storage Condition | -20°C Freezer |
| Application | CI-1040 (PD184352) is an orally active, highly specific small molecule inhibitor of MEK, with an IC50 value of 17 nM for MEK1. |
| HTC | 2924299090 |
| PubChem ID | 329823755 |
| MDL Number | MFCD02683961 |
| SMILES | Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F |
| InChI | 1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) |
| InChI Key | GFMMXOIFOQCCGU-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/55536_1_212631_79_3.pdf |
| Use of | CI-1040 (PD184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. Properties Articles13 Name pd 184352 Synonym More Synonyms PD184352 (CI-1040) Biological Activity Description CI-1040 (PD184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> MEK Research Areas >> Cancer MEK1:17 nM (IC50) References [1]. Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003 Oct;30(5 Suppl 16):105-16. [2]. Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20(10):1961-8. Chemical & Physical Properties Exact Mass 477.975647 PSA 50.36000 Index of Refraction 1.656 InChIKey GFMMXOIFOQCCGU-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H400 Precautionary Statements P273 Hazard Codes N Safety Phrases 60-61 HS Code 2924299090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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