CAS Number212142-18-2
SynonymsN-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1); PTK787; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate; Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1); 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1); N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate; N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1); (4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1); (4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate; Vatalanib; Vatalanib succinate; PTK/ZK
Molecular FormulaC24H21O4N4Cl1
Molecular Weight464.91
Purity98.00%
Boiling Point587.8ºC at 760 mmHg
Melting Point195ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 212142-18-2 |
| Catalog No. | 2A-9055528 |
| Chinese Name | 琥珀酸瓦他拉尼 |
| Synonyms | N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1); PTK787; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate; Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1); 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1); N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate; N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1); (4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1); (4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate; Vatalanib; Vatalanib succinate; PTK/ZK |
| Molecular Formula | C24H21O4N4Cl1 |
| Molecular Weight | 464.91 |
| Purity | 98.00 |
| Boiling Point | 587.8ºC at 760 mmHg |
| Melting Point | 195ºC |
| Application | Vatalanib (PTK787) succinate is a potent orally active VEGFR inhibitor with IC50 values of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms and PDGFR |
| MDL Number | MFCD08435979 |
| SMILES | Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1.O=C(O)CCC(=O)O |
| InChI | InChI=1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6)(H,7,8) |
| InChI Key | LLDWLPRYLVPDTG-UHFFFAOYSA-N |
| MSDS | msds/55528_1_212142_18_2.pdf |
| Transport Info | Product name: Vatalanib succinate |
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