CAS Number125354-16-7
SynonymsN-DEBENZOYL-N-(TERT-BUTOXYCARBONYL)TAXOL; 10-Acetyldocetaxel; 10-Acetyltaxotere; Docetaxal; DOCETAXOL; DOCETAXEL TRIHYDRATE; DOCETAXEL, TRIHYDRATE; DOCETAXEL,TRIHYDRATE
Molecular FormulaC45H55NO15
Molecular Weight849.92
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point901.4±65.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 125354-16-7 |
| Catalog No. | 2A-9051676 |
| Chinese Name | 多西他赛 |
| Synonyms | N-DEBENZOYL-N-(TERT-BUTOXYCARBONYL)TAXOL; 10-Acetyldocetaxel; 10-Acetyltaxotere; Docetaxal; DOCETAXOL; DOCETAXEL TRIHYDRATE; DOCETAXEL, TRIHYDRATE; DOCETAXEL,TRIHYDRATE |
| Molecular Formula | C45H55NO15 |
| Molecular Weight | 849.92 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 901.4±65.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Docetaxal (10-Acetyl docetaxel; PNU-101383) is an analogue of Docetaxel (HY-B0011). Docetaxal is a microtubule disassembly inhibitor with antimitotic activity. Docetaxal is cytotoxic to mouse leukemia |
| HTC | 2932999099 |
| SMILES | CC(=O)OC1C(=O)C2(C)C(O)CC3OCC3(OC(C)=O)C2C(OC(=O)c2ccccc2)C2(O)CC(OC(=O)C(O)C(NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C1C2(C)C |
| InChI | InChI=1S/C45H55NO15/c1-23-28(58-39(53)33(50)32(26-16-12-10-13-17-26)46-40(54)61-41(4,5)6)21-45(55)37(59-38(52)27-18-14-11-15-19-27)35-43(9,29(49)20-30-44(35,22-56-30)60-25(3)48)36(51)34(57-24(2)47)31(23)42(45,7)8/h10-19,28-30,32-35,37,49-50,55H,20-22H2,1-9H3,(H,46,54)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1 |
| InChI Key | LEMYAXKYCOBYOJ-OAGWZNDDSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/51676_1_125354_16_7.pdf |
| Use of | Docetaxal (10-Acetyl docetaxel; PNU-101383), an analog of Docetaxel (HY-B0011), is a microtubule disassembly inhibitor, with antimitotic activity. Docetaxal has cytotoxicity for murine leukemic cells[1]. Properties Name Docetaxel Synonym More Synonyms Docetaxal Biological Activity Description Docetaxal (10-Acetyl docetaxel; PNU-101383), an analog of Docetaxel (HY-B0011), is a microtubule disassembly inhibitor, with antimitotic activity. Docetaxal has cytotoxicity for murine leukemic cells[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin References Chemical & Physical Properties Molecular Formula C45H55NO15 Exact Mass 849.357178 PSA 230.52000 Index of Refraction 1.606 InChIKey LEMYAXKYCOBYOJ-OAGWZNDDSA-N Safety Information HS Code 2932999099 Synthetic Route 1246748-59-3 125354-16-7 10-acetyl-2'... 1144034-14-9 125354-16-7 Literature: Nevarez, Danielle M.; Mengistu, Yemane A.; Nawarathne, Irosha N.; Walker, Kevin D. Journal of the American Chemical Society, 2009 , vol. 131, p. 5994 - 6002 114915-13-8 125354-16-7 Literature: Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190 Precursor & DownStream Precursor 5 CAS#:1144034-14-9 10-acetyl-2'-TB... CAS#:342613-14-3 2'-TBS-docetaxel CAS#:24424-99-5 Di-tert-butyl d... CAS#:33069-62-4 Paclitaxel DownStream 1 CAS#:133524-70-6 3'-N-debenzoyltaxol |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in API & Advanced Intermediates | ||
|---|---|---|
| Azithromycin monohydrate | 121470-24-4 | 2A-9051424 |
| (+)-Tramadol | 123154-38-1 | 2A-9051546 |
| Topotecan acetate | 123948-88-9 | 2A-9051602 |
| Losartan carboxylic acid | 124750-92-1 | 2A-9051640 |
| Cbz-Valaciclovir | 124832-31-1 | 2A-9051649 |
| Rifapentine hydrochloride | 127923-87-9 | 2A-9051856 |
| (R)-Citalopram | 128196-02-1 | 2A-9051879 |
| Alendronate sodium | 129318-43-0 | 2A-9051958 |
| Aripiprazole | 129722-12-9 | 2A-9051984 |
| Carbamazepine-D10 | 132183-78-9 | 2A-9052177 |
| Browse all API & Advanced Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS