CAS Number132183-78-9
Synonyms(H)-5H-Dibenzo[b,f]azepine-5-carboxamide; 5H-Dibenz[b,f]azepine-d-5-carboxamide
Molecular FormulaC15H2D10N2O
Molecular Weight246.33
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point411.0±48.0 °C at 760 mmHg
Appearanceliquid
EINECS200-659-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 132183-78-9 |
| Catalog No. | 2A-9052177 |
| Chinese Name | 5H-二苯并[B,F]氮杂卓-5-甲酰胺-D10 |
| Synonyms | (H)-5H-Dibenzo[b,f]azepine-5-carboxamide; 5H-Dibenz[b,f]azepine-d-5-carboxamide |
| Molecular Formula | C15H2D10N2O |
| Molecular Weight | 246.33 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 411.0±48.0 °C at 760 mmHg |
| Appearance | liquid |
| Storage Condition | ?20°C |
| Application | Carbamazepine-D10 (CBZ-D10) is deuterium-labeled carbamazepine. Carbamazepine (CBZ) is a sodium channel blocker and an anticonvulsant [1][2]. |
| EINECS | 200-659-6 |
| PubChem ID | 329774828 |
| MDL Number | MFCD01073507 |
| SMILES | [2H]C1=C2N(C(N)=O)C3=C(C([2H])=C([2H])C([2H])=C3[2H])C([2H])=C([2H])C2=C([2H])C([2H])=C1[2H] |
| InChI | 1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)/i1D,2D,3D,4D,5D,6D,7D,8D,9D,10D |
| InChI Key | FFGPTBGBLSHEPO-LHNTUAQVSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| Bioactivity | Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. References [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 411.0±48.0 °C at 760 mmHg Molecular Formula C15H2D10N2O Molecular Weight 246.330 Flash Point 202.4±29.6 °C Exact Mass 246.157730 PSA 46.33000 LogP 2.67 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.670 InChIKey FFGPTBGBLSHEPO-LHNTUAQVSA-N SMILES NC(=O)N1c2ccccc2C=Cc2ccccc21 Storage condition ?20°C |
| Use of | Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2]. Properties Name 1,2,3,4,5,6,7,8,9,10-decadeuteriobenzo[b][1]benzazepine-11-carboxamide Synonym More Synonyms Biological Activity Description Carbamazepine-D10 (CBZ-D10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. References [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. Chemical & Physical Properties Molecular Formula C15H2D10N2O Exact Mass 246.157730 PSA 46.33000 Index of Refraction 1.670 InChIKey FFGPTBGBLSHEPO-LHNTUAQVSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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