CAS Number124750-92-1
Synonyms2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid; E-3174; Losartan carboxylic acid; 2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid; Carboxylosartan; 2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid; Exp3174; EXP-3174
Molecular FormulaC22H21ClN6O2
Molecular Weight436.89
Purity≥95 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point707.8±70.0 °C at 760 mmHg
Melting Point130-132ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 124750-92-1 |
| Catalog No. | 2A-9051640 |
| Chinese Name | 氯沙坦 |
| Synonyms | 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid; E-3174; Losartan carboxylic acid; 2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid; Carboxylosartan; 2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid; Exp3174; EXP-3174 |
| Molecular Formula | C22H21ClN6O2 |
| Molecular Weight | 436.89 |
| Purity | ≥95 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 707.8±70.0 °C at 760 mmHg |
| Melting Point | 130-132ºC |
| Appearance | solid |
| Storage Condition | -20°C Freezer |
| Application | Losartan Carboxylic Acid (E-3174) is the active carboxylic acid metabolite of Losartan and an angiotensin II receptor type 1 (AT1) antagonist. The Ki values for rat AT1B/AT1A and human AT1 were 0.97 |
| MDL Number | MFCD00871928 |
| SMILES | Clc1nc([n](c1C(=O)O)Cc2ccc(cc2)c3c(cccc3)c4[nH]nnn4)CCCC |
| InChI | 1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28) |
| InChI Key | ZEUXAIYYDDCIRX-UHFFFAOYSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352106 |
| MSDS | msds/51640_1_124750_92_1.pdf |
| Transport Info | Product name: EXP 3174 |
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