CAS Number104632-25-9
Synonyms2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2); (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride; Pramipexole hydrochloride; Pramipexole dihydrochloride; MFCD00876894; (S)-Pramipexole Dihydrochloride; (6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride; (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride; Pramipexole (dihydrochloride)
Molecular FormulaC10H19Cl2N3S
Molecular Weight284.25
Purity>98 (HPLC)%
Boiling Point378ºC at 760 mmHg
Melting Point288-290ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 104632-25-9 |
| Catalog No. | 2A-9050128 |
| Chinese Name | 盐酸普拉克索 |
| Synonyms | 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2); (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride; Pramipexole hydrochloride; Pramipexole dihydrochloride; MFCD00876894; (S)-Pramipexole Dihydrochloride; (6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride; (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride; Pramipexole (dihydrochloride) |
| Molecular Formula | C10H19Cl2N3S |
| Molecular Weight | 284.25 |
| Purity | >98 (HPLC) |
| Boiling Point | 378ºC at 760 mmHg |
| Melting Point | 288-290ºC |
| Appearance | powder |
| Storage Condition | Desiccate at RT |
| Application | Pramipexole dihydrochloride is a partial and complete D2S, D2L, D3 and D4 receptor agonist with Ki of 3.9, 2.2, 0.5 and 5.1 nM respectively. |
| HTC | 2934999090 |
| PubChem ID | 329770694 |
| MDL Number | MFCD00876894 |
| SMILES | Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1 |
| InChI | 1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1 |
| InChI Key | QMNWXHSYPXQFSK-KLXURFKVSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/50128_1_104632_25_9.pdf |
| Use of | Properties Name pramipexole hydrochloride anhydrous Synonym More Synonyms Pramipexole dihydrochloride Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Mierau J, Schneider FJ, Ensinger HA et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36. [2]. El-Mallakh RS, Penagaluri P, Kantamneni A et al. Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review. Psychiatr Q. 2010 Sep;81(3):207-13. [3]. Perez-Lloret S, Rey MV, Ratti L, Rascol O. Pramipexole for the treatment of early Parkinson's disease. Expert Rev Neurother. 2011 Jul;11(7):925-35. [4]. Hametner EM, Seppi K, Poewe W. Pramipexole extended release in Parkinson's disease. Expert Rev Neurother. 2011 Sep;11(9):1229-34. [5]. Hametner EM, Seppi K, Poewe W. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease. Clin Interv Aging. 2012;7:83-8. Chemical & Physical Properties Exact Mass 283.067688 PSA 79.18000 LogP 4.15830 InChIKey QMNWXHSYPXQFSK-KLXURFKVSA-N Storage condition Desiccate at RT Safety Information Hazard Codes Xi RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route (S)-pramipexole... CAS#:943319-02-6 Pramipexole dih... CAS#:104632-25-9 (6S)-2-Amino-6-... CAS#:106006-84-2 Pramipexole dih... CAS#:104632-25-9 Literature: Ravinder; Rajeswar Reddy; Panasa Reddy; Bandichhor, Rakeshwar Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4908 - 4913 Pramipexole CAS#:104632-26-0 Pramipexole dih... CAS#:104632-25-9 Literature: Helm AG; CF Pharma Gyogyszergyarto Kft. Patent: EP1878731 A1, 2008 ; Location in patent: Page/Page column 11 ; Precursor & DownStream Precursor 8 CAS#:106006-84-2 (6S)-2-Amino-6-... CAS#:104632-26-0 Pramipexole CAS#:1001648-71-0 rac-cis-7-Hydro... CAS#:106006-83-1 4,5,6,7-TETRAHY... DownStream 1 CAS#:104632-26-0 Pramipexole |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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