CAS Number102767-28-2
Synonyms(2S)-2-(2-Oxopyrrolidin-1-yl)butanamide; levetiracetamum; 2(S)-(2-oxopyrrolidin-1-yl)butyramide; KEPPRA; (2S)-2-(2-Oxo-1-pyrrolidinyl)butanamide; (S)-Etiracetam; Etiracetam levo-isomer; EINECS 200-659-6; ucb L059; (aS)-a-Ethyl-2-oxo-1-pyrrolidineacetamide; (S)-2-(2-Oxopyrrolidin-1-yl)Butanamide; SIB S1; (S)-2-(2-Oxo-1-pyrrolidinyl)butyramide; MFCD03265610; SIB-S1; (-)-(S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide; Keppra XR; Levetiracetam
Molecular FormulaC8H14N2O2
Molecular Weight170.21
Purity99.00%
Density1.2±0.1 g/cm3
Boiling Point395.9±25.0 °C at 760 mmHg
Melting Point118-119°C
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 102767-28-2 |
| Catalog No. | 2A-9049931 |
| Chinese Name | 左乙拉西坦 |
| Synonyms | (2S)-2-(2-Oxopyrrolidin-1-yl)butanamide; levetiracetamum; 2(S)-(2-oxopyrrolidin-1-yl)butyramide; KEPPRA; (2S)-2-(2-Oxo-1-pyrrolidinyl)butanamide; (S)-Etiracetam; Etiracetam levo-isomer; EINECS 200-659-6; ucb L059; (aS)-a-Ethyl-2-oxo-1-pyrrolidineacetamide; (S)-2-(2-Oxopyrrolidin-1-yl)Butanamide; SIB S1; (S)-2-(2-Oxo-1-pyrrolidinyl)butyramide; MFCD03265610; SIB-S1; (-)-(S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide; Keppra XR; Levetiracetam |
| Molecular Formula | C8H14N2O2 |
| Molecular Weight | 170.21 |
| Purity | 99.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 395.9±25.0 °C at 760 mmHg |
| Melting Point | 118-119°C |
| Appearance | White crystalline powder |
| Storage Condition | room temperature, sealed |
| Application | Levetiracetam (UCB L059) is an anti-epileptic compound. |
| HTC | 2933990090 |
| PubChem ID | 329831325 |
| SMILES | CCC(C(N)=O)N1CCCC1=O |
| InChI | InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m1/s1 |
| InChI Key | HPHUVLMMVZITSG-LURJTMIESA-N |
| Hazard Symbols | transportation |
| Bioactivity | Levetiracetam(UCB L059) is a novel anticonvulsant with antihyperalgesic efficacy in inflammatory pain.Target: Calcium ChannelLevetiracetam is used to control some types of seizures in patients with epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to use it. The exact mechanism for levetiracetam is unknown. However, the drug binds to a synaptic vesicle protein, SV2A, which is believed to impede nerve conduction across synapses [1].Levetiracetam (10-200 mg/kg), ibuprofen (12.5-100 mg/kg), celecoxib (3.75-30 mg/kg), paracetamol (50-200 mg/kg), caffeine (15-100 mg/kg), and 2-drug combinations of levetiracetam with analgesics/caffeine produced a significant, dose-dependent reduction of inflammatory hyperalgesia. Isobolographic analysis revealed that levetiracetam exerts a synergistic interaction with analgesics, with approximately 7-, 9-, and 11-fold reduction of doses of both drugs in combination of levetiracetam with paracetamol, celecoxib, and ibuprofen, respectively. Analysis of the log dose-response curves for levetiracetam (1-50 mg/kg) in the presence of caffeine (10 mg/kg) and levetiracetam applied alone also revealed a synergistic interaction. Levetiracetam's ED50 in the presence of caffeine was reduced approximately 11-fold [2].Clinical indications: Epilepsy; Social phobiaFDA Approved Date: November 2008Toxicity: depression; hallucinations; suicidal thoughts Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. Meehan AL， et al. A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J Neurophysiol. 2011 Sep;106(3):1227-39. [2]. Tomi MA, et al. Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. J Pain. 2013 Nov;14(11):1371-82. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 395.9±25.0 °C at 760 mmHg Melting Point 118-119°C Molecular Formula C8H14N2O2 Molecular Weight 170.209 Flash Point 193.2±23.2 °C Exact Mass 170.105530 PSA 63.40000 LogP -0.67 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.519 InChIKey HPHUVLMMVZITSG-LURJTMIESA-N SMILES CCC(C(N)=O)N1CCCC1=O |
| Use of | Properties Articles83 Name levetiracetam Synonym More Synonyms Levetiracetam Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. Meehan AL， et al. A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J Neurophysiol. 2011 Sep;106(3):1227-39. [2]. Tomi MA, et al. Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. J Pain. 2013 Nov;14(11):1371-82. Chemical & Physical Properties Molecular Formula C8H14N2O2 Exact Mass 170.105530 PSA 63.40000 LogP -0.67 Index of Refraction 1.519 InChIKey HPHUVLMMVZITSG-LURJTMIESA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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