CAS Number78287-27-1
SynonymsSN 22; (4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 20(S)-7-ethylcamptothecin; (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethyl-20(S)-camptothecin
Molecular FormulaC22H20N2O4
Molecular Weight376.41
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point752.9±60.0 °C at 760 mmHg
Melting Point236-241ºC
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78287-27-1 |
| Catalog No. | 2A-9048207 |
| Chinese Name | 7-乙基喜树碱 |
| Synonyms | SN 22; (4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 20(S)-7-ethylcamptothecin; (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethyl-20(S)-camptothecin |
| Molecular Formula | C22H20N2O4 |
| Molecular Weight | 376.41 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 752.9±60.0 °C at 760 mmHg |
| Melting Point | 236-241ºC |
| Appearance | solid |
| Storage Condition | -20°C Freezer |
| Packaging | III |
| Application | 7-Ethylcamptothecin 是喜树碱类似物之一。 喜树碱 (CPT) 是一种从喜树 (camptothecin analogues) 中分离出的细胞毒性生物碱,对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。 |
| HTC | 2942000000 |
| PubChem ID | 329777468 |
| MDL Number | MFCD06657922 |
| SMILES | CCc1c2CN3C(=O)C4=C(C=C3c2nc5ccccc15)[C@@](O)(CC)C(=O)OC4 |
| InChI | 1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1 |
| InChI Key | MYQKIWCVEPUPIL-QFIPXVFZSA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| MSDS | msds/48207_1_78287_27_1.pdf |
| Bioactivity | 7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminate, is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Wang, X.,et al. New Route for Conversion of Camptothecin to 7-Ethylcamptothecin and 7-Propylcamptothecin. Synthetic Communications, 2007,37(3), 519-523. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 752.9±60.0 °C at 760 mmHg Melting Point 236-241ºC Molecular Formula C22H20N2O4 Molecular Weight 376.405 Flash Point 409.1±32.9 °C Exact Mass 376.142303 PSA 81.42000 LogP 2.60 Vapour Pressure 0.0±2.6 mmHg at 25°C Index of Refraction 1.713 InChIKey MYQKIWCVEPUPIL-QFIPXVFZSA-N SMILES CCc1c2c(nc3ccccc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(O)CC Storage condition -20°C Freezer |
| Use of | Properties Name 7-Ethylcamptothecin Synonym More Synonyms 7-Ethylcamptothecin Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Wang, X.,et al. New Route for Conversion of Camptothecin to 7-Ethylcamptothecin and 7-Propylcamptothecin. Synthetic Communications, 2007,37(3), 519-523. Chemical & Physical Properties Molecular Formula C22H20N2O4 Exact Mass 376.142303 PSA 81.42000 Index of Refraction 1.713 InChIKey MYQKIWCVEPUPIL-QFIPXVFZSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | 模块14. 运输信息 联合国分类： 第1项 毒害品。 UN编号： 1544 正式运输名称： 生物碱, 固体, 不另作详细说明 包装等级： III |
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