EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Deoxynojirimycin hydrochloride
Deoxynojirimycin hydrochloride structure, CAS 73285-50-4

Deoxynojirimycin hydrochloride

CAS Number73285-50-4

Synonyms3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-, hydrochloride (1:1); (+)-(2R,3R,4R,5S)-2-hydroxymethyl-3,4,5-trihydroxypiperidine hydrochloride; (+)-1-deoxynojirimycin hydrochloride; (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1); (+-)-1-Chlor-8,9-dihydro-inden; 1H-Indene,1-chloro-3a,7a-dihydro; (1R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidinium chloride; (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride (1:1); Duvoglustat hydrochloride; 1,5-dideoxy-1,5-imino-D-glucitol hydrochloride

Molecular FormulaC6H14O4N1Cl1

Molecular Weight199.63

Purity98.00%

Density1.456 g/cm3

Boiling Point361.1ºC at 760 mmHg

Melting Point195-196ºC

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-0201313 Purity: 98.00%
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 73285-50-4 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number73285-50-4
Catalog No.2A-0201313
Chinese Name(2R,3R,4R,5S)-2-羟甲基-3,4,5-三羟基哌啶盐酸盐
Synonyms3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-, hydrochloride (1:1); (+)-(2R,3R,4R,5S)-2-hydroxymethyl-3,4,5-trihydroxypiperidine hydrochloride; (+)-1-deoxynojirimycin hydrochloride; (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol hydrochloride (1:1); (+-)-1-Chlor-8,9-dihydro-inden; 1H-Indene,1-chloro-3a,7a-dihydro; (1R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidinium chloride; (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride (1:1); Duvoglustat hydrochloride; 1,5-dideoxy-1,5-imino-D-glucitol hydrochloride
Molecular FormulaC6H14O4N1Cl1
Molecular Weight199.63
Purity98.00
Density1.456 g/cm3
Boiling Point361.1ºC at 760 mmHg
Melting Point195-196ºC
Storage Condition2-8°C, store in inert gas
Application1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is an orally available α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride inhibits postprandial blood sugar and prevents diabetes. 1
PubChem ID24278397
MDL NumberMFCD00133247
SMILESCl.OCC1NCC(O)C(O)C1O
InChIInChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
InChI KeyZJIHMALTJRDNQI-VFQQELCFSA-N
MSDSmsds/47573_1_73285_50_4.pdf
Bioactivity1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Metabolic Disease In Vivo 1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect [3]. 1-Deoxynojirimycin hydrochloride significantly improves insulin sensitivity via activating insulin signaling PI3K/AKT pathway in skeletal muscle of db/db mice[3]. Animal Model: db/db mice[3] Dosage: 20, 40, 80 mg/kg Administration: Intravenously; daily for four weeks Result: Significantly reduced body weight, blood glucose and serum insulin levels; Improved glucose tolerance and insulin tolerance. References [1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232. [3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14. Chemical & Physical Properties Density 1.456 g/cm3 Boiling Point 361.1ºC at 760 mmHg Melting Point 195-196ºC Molecular Formula C6H14ClNO4 Molecular Weight 199.633 Flash Point 197.3ºC Exact Mass 199.061142 PSA 92.95000 InChIKey ZJIHMALTJRDNQI-VFQQELCFSA-N SMILES Cl.OCC1NCC(O)C(O)C1O
Use of1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. Properties Articles38 Name Deoxynojirimycin hydrochloride Synonym More Synonyms 1-Deoxynojirimycin hydrochloride Biological Activity Description 1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features[1][2]. Related Catalog Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Metabolic Disease References [1]. Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600. [2]. Chaluntorn Vichasilp,et al. Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology. Volume 45, Issue 2, March 2012, Pages 226-232. [3]. Liu Q, et al. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice. Molecules. 2015 Dec 4;20(12):21700-14. Chemical & Physical Properties Exact Mass 199.061142 PSA 92.95000 InChIKey ZJIHMALTJRDNQI-VFQQELCFSA-N SMILES Cl.OCC1NCC(O)C(O)C1O
Transport InfoProduct name: 1-Deoxynomycin hydrochloride
Related Products in Specialty Chemicals
Dicyclopropylamine73121-95-62A-9047552
2-(2-Aminothiazol-4-yl)glyoxylic acid73150-67-12A-9047554
1-(3-Chlorophenyl)-1,2-propanedione10557-17-22A-9047555
4-(4-Oxocyclohexyl)benzonitrile73204-07-62A-9047558
4-Benzoylphenyl methyl sulfoxide73241-57-32A-9047564
2-Hydroxy-6-methylbenzonitrile73289-66-42A-9047575
Piperazin-1-ylpyrrolidin-1-ylmethanone73331-93-82A-9047579
(-)-2,3-O-Isopropylidene-D-threitol73346-74-42A-9047581
5,7-Dimethylbenzothiazol-2-ylamine73351-87-82A-9047584
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate73360-56-22A-9047585
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA