CAS Number66357-59-3
SynonymsSostril; Terposen; Raniben; Ultidine; Ranitidine HCl salt; Noctone; Taural; Zantac; Trigger; UNII-BK76465IHM; Raniplex; Ranidil; Zantic; Ranitidine hydrochloride; EINECS 266-332-5; MFCD00069339; Azantac; Ulcex; Ranitidine HCl
Molecular FormulaC13H23ClN4O3S
Molecular Weight350.86
Purity98.00%
Melting Point134°C (dec.)
AppearanceOff-white crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66357-59-3 |
| Catalog No. | 2A-9046422 |
| Chinese Name | 盐酸雷尼替丁 |
| Synonyms | Sostril; Terposen; Raniben; Ultidine; Ranitidine HCl salt; Noctone; Taural; Zantac; Trigger; UNII-BK76465IHM; Raniplex; Ranidil; Zantic; Ranitidine hydrochloride; EINECS 266-332-5; MFCD00069339; Azantac; Ulcex; Ranitidine HCl |
| Molecular Formula | C13H23ClN4O3S |
| Molecular Weight | 350.86 |
| Purity | 98.00 |
| Melting Point | 134°C (dec.) |
| Appearance | Off-white crystalline solid |
| Water Solubility | H2O: 1.8 mg/mL |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Ranitidine (Zantac) is a histamine H2-receptor antagonist with an IC50 of 3.3uM. |
| HTC | 2933990090 |
| PubChem ID | 7847739 |
| SMILES | [H+].[Cl-].CNC(/NCCSCc1oc(CN(C)C)cc1)=C\[N+]([O-])=O |
| InChI | InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9+; |
| InChI Key | InChIKey=GGWBHVILAJZWKJ-KJEVSKRMSA-N |
| Bioactivity | Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease References [1]. Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9. [2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81. Chemical & Physical Properties Melting Point 134°C (dec.) Molecular Formula C13H23ClN4O3S Molecular Weight 350.865 Exact Mass 350.117950 PSA 111.56000 LogP 3.56600 Storage condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere Water Solubility H2O: 1.8 mg/mL |
| Use of | Properties Articles51 Name ranitidine hydrochloride Synonym More Synonyms Ranitidine hydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Metabolic Disease References [2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81. Chemical & Physical Properties Exact Mass 350.117950 PSA 111.56000 LogP 3.56600 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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