CAS Number64887-14-5
Synonyms6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione,hydrochloride
Molecular FormulaC20H30ClN5O3
Molecular Weight423.937
Purity98.00%
Boiling Point549ºC at 760 mmHg
Melting Point156-158ºC
AppearanceWhite or off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 64887-14-5 |
| Catalog No. | 2A-9046160 |
| Chinese Name | 盐酸乌拉地尔 |
| Synonyms | 6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione,hydrochloride |
| Molecular Formula | C20H30ClN5O3 |
| Molecular Weight | 423.937 |
| Purity | 98.00 |
| Boiling Point | 549ºC at 760 mmHg |
| Melting Point | 156-158ºC |
| Appearance | White or off-white crystalline powder |
| Water Solubility | H2O: soluble |
| Storage Condition | Desiccate at RT |
| Application | Urapidil hydrochloride is an α1-adrenoceptor antagonist and a 5-HT1A receptor agonist. |
| HTC | 3004909090 |
| PubChem ID | 10256649 |
| SMILES | COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1.Cl |
| InChI | InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H |
| InChI Key | KTMLZVUAXJERAT-UHFFFAOYSA-N |
| Use of | Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.Target: α1-adrenoceptor; 5-HT1A receptorUrapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system [1]. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia [2]. Properties Articles31 Name Urapidil Hydrochloride Synonym More Synonyms Urapidil Hydrochloride Biological Activity Description Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.Target: α1-adrenoceptor; 5-HT1A receptorUrapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system [1]. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Gross, G., G. Hanft, and N. Kolassa, Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch Phar [2]. Buch, J., Urapidil, a dual-acting antihypertensive agent: Current usage considerations. Adv Ther, 2010. 27(7): p. 426-43. Chemical & Physical Properties Exact Mass 423.203705 PSA 71.74000 LogP 1.59470 InChIKey KTMLZVUAXJERAT-UHFFFAOYSA-N Storage condition Desiccate at RT Water Solubility H2O: soluble Safety Information Signal Word Warning Hazard Statements H302 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn:Harmful; Risk Phrases R22 Safety Phrases S36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS YQ9862000 HS Code 3004909090 |
| Transport Info | Product Name: Urapidil Hydrochloride |
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