CAS Number57757-57-0
SynonymsDSP; 1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione; MFCD00042045; 1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione; Di(N-succinimidyl) 3,3'-dithiodipropionate; dithiobis(succinimidyl propionate); 1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione); (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate; EINECS 260-931-5
Molecular FormulaC14H16N2O8S2
Molecular Weight404.42
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point560.1±60.0 °C at 760 mmHg
Melting Point128-133 °C
Appearancepowder
EINECS260-931-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57757-57-0 |
| Catalog No. | 2A-9044893 |
| Chinese Name | 3,3'-二硫代二丙酸二(N-羟基丁二酰亚胺)酯[交联剂] |
| Synonyms | DSP; 1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione; MFCD00042045; 1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione; Di(N-succinimidyl) 3,3'-dithiodipropionate; dithiobis(succinimidyl propionate); 1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione); (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate; EINECS 260-931-5 |
| Molecular Formula | C14H16N2O8S2 |
| Molecular Weight | 404.42 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 560.1±60.0 °C at 760 mmHg |
| Melting Point | 128-133 °C |
| Appearance | powder |
| Water Solubility | chloroform: 50 mg/mL |
| Storage Condition | Room temperature, 2-8°C, sealed, protected from li |
| Application | DSP Crosslinker is a cleavable ADC linker used for the synthesis of antibody drug conjugates (ADC). |
| EINECS | 260-931-5 |
| HTC | 2930909090 |
| PubChem ID | 24893777 |
| MDL Number | MFCD00042045 |
| SMILES | O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O |
| InChI | 1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2 |
| InChI Key | FXYPGCIGRDZWNR-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1518074 |
| NACRES Code | NC.07 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S36 |
| Bioactivity | DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology Target Cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 560.1±60.0 °C at 760 mmHg Melting Point 128-133 °C Molecular Formula C14H16N2O8S2 Molecular Weight 404.415 Flash Point 292.6±32.9 °C Exact Mass 404.034790 PSA 177.96000 LogP -1.66 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.625 InChIKey FXYPGCIGRDZWNR-UHFFFAOYSA-N SMILES O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O Storage condition 2-8°C Water Solubility chloroform: 50 mg/mL |
| Use of | DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1]. Properties Articles31 Name 3,3'-dithiodipropionic acid di(n-succinimidyl ester) Synonym More Synonyms DSP Crosslinker Biological Activity Description DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Research Areas >> Inflammation/Immunology In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717. Chemical & Physical Properties Molecular Formula C14H16N2O8S2 Exact Mass 404.034790 PSA 177.96000 LogP -1.66 Index of Refraction 1.625 InChIKey FXYPGCIGRDZWNR-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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