CAS Number57294-38-9
Synonyms4-[(1,1-dimethylethoxycarbonyl)amino]butanoic acid; 4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid; N-Boc-g-aminobutyric Acid; Glutamic acid, 1-(1,1-dimethylethyl) ester; Boc-GABA-OH; MFCD00037313; 4-[(tert-butoxycarbonyl)amino]butanoic acid; 4-(tert-butyloxycarbonylamino)butyric acid; 4-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid; 4-[(tert-butoxy)carbonylamino]butanoic acid; 4-(Boc-amino)butyric acid; Boc-GABA; N-Boc-gamma-aminobutyric acid; N-(tert-butyloxycarbonyl)-4-aminobutyric acid; 4-(tert-Butoxycarbonylamino)butyric acid; N-Boc-γ-aminobutyric acid
Molecular Formula(CH3)3COCONH(CH2)3CO2H
Molecular Weight203.24
Purity97%
Density1.1±0.1 g/cm3
Boiling Point78-82 °C/0.2 mmHg (lit.)
Melting Point55-57 °C (lit.)
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57294-38-9 |
| Catalog No. | 2A-9044803 |
| Chinese Name | N-Boc-γ-氨基丁酸 |
| Synonyms | 4-[(1,1-dimethylethoxycarbonyl)amino]butanoic acid; 4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid; N-Boc-g-aminobutyric Acid; Glutamic acid, 1-(1,1-dimethylethyl) ester; Boc-GABA-OH; MFCD00037313; 4-[(tert-butoxycarbonyl)amino]butanoic acid; 4-(tert-butyloxycarbonylamino)butyric acid; 4-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)butanoic acid; 4-[(tert-butoxy)carbonylamino]butanoic acid; 4-(Boc-amino)butyric acid; Boc-GABA; N-Boc-gamma-aminobutyric acid; N-(tert-butyloxycarbonyl)-4-aminobutyric acid; 4-(tert-Butoxycarbonylamino)butyric acid; N-Boc-γ-aminobutyric acid |
| Molecular Formula | (CH3)3COCONH(CH2)3CO2H |
| Molecular Weight | 203.24 |
| Purity | 97 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 78-82 °C/0.2 mmHg (lit.) |
| Melting Point | 55-57 °C (lit.) |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Application | Boc-GABA-OH is a PROTAC linker that can be used to synthesize UNC6852. UNC6852 is a PROTAC degrader targeting EED. |
| PubChem ID | 24870468 |
| MDL Number | MFCD00037313 |
| SMILES | CC(C)(C)OC(=O)NCCCC(O)=O |
| InChI | 1S/C9H17NO4/c1-9(2,3)14-8(13)10-6-4-5-7(11)12/h4-6H2,1-3H3,(H,10,13)(H,11,12) |
| InChI Key | HIDJWBGOQFTDLU-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1869578 |
| NACRES Code | NA.22 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/44803_1_57294_38_9.pdf |
| Bioactivity | Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether References [1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 78-82 ºC Melting Point 55-59 °C Molecular Formula C9H17NO4 Molecular Weight 203.236 Flash Point 113 ºC Exact Mass 203.115753 PSA 75.63000 LogP 0.77 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.476 InChIKey HIDJWBGOQFTDLU-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCC(=O)O Storage condition 2-8°C |
| Use of | Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC[1]. Properties Name 4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid Synonym More Synonyms Boc-GABA-OH Biological Activity Description Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether References [1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. Chemical & Physical Properties Molecular Formula C9H17NO4 Exact Mass 203.115753 PSA 75.63000 Index of Refraction 1.476 InChIKey HIDJWBGOQFTDLU-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)NCCCC(=O)O |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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