CAS Number57477-39-1
Synonyms5-hydroxy-3-(1-methylpiperidin-4-yl)indole; 3-(1-methyl-piperidin-4-yl)-indol-5-ol; 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol; BRL-54443; BRL 54443; Tocris-1129; 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol; Lopac-B-173; 3-(1-methylpiperidin-4-yl)1H-indol-5-ol
Molecular FormulaC14H18O1N2
Molecular Weight230.31
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point431.5±45.0 °C at 760 mmHg
Appearancesolid | white
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57477-39-1 |
| Catalog No. | 2A-9044842 |
| Chinese Name | 3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇 |
| Synonyms | 5-hydroxy-3-(1-methylpiperidin-4-yl)indole; 3-(1-methyl-piperidin-4-yl)-indol-5-ol; 3-(1-Methylpiperidin-4-yl)-1H-indol-5-ol; BRL-54443; BRL 54443; Tocris-1129; 3-(1-Methyl-4-piperidinyl)-1H-indol-5-ol; Lopac-B-173; 3-(1-methylpiperidin-4-yl)1H-indol-5-ol |
| Molecular Formula | C14H18O1N2 |
| Molecular Weight | 230.31 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 431.5±45.0 °C at 760 mmHg |
| Appearance | solid | white |
| Water Solubility | H2O: 50 mg/mL |
| Storage Condition | 2-8°C |
| Application | BRL 54443 is a 5-HT1E/1F receptor agonist with pKi of 8.7 and 8.9 respectively. It is more than 30 times more inhibitory than other 5-HT and dopamine receptors. |
| HTC | 2933990090 |
| PubChem ID | 5580999 |
| MDL Number | MFCD01861184 |
| SMILES | CN1CCC(c2c[nH]c3ccc(O)cc23)CC1 |
| InChI | InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3 |
| InChI Key | WKNFADCGOAHBPG-UHFFFAOYSA-N |
| MSDS | msds/44842_1_57477_39_1.pdf |
| Use of | Properties Name 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol Synonym More Synonyms BRL-54443 Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Cardiovascular Disease References [2]. McKune CM, et al. Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. [3]. Klein MT, et al. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302. [4]. Granados-Soto V, et al. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. Chemical & Physical Properties Molecular Formula C14H18N2O Exact Mass 230.141907 PSA 39.26000 Appearance of Characters solid | white Index of Refraction 1.646 InChIKey WKNFADCGOAHBPG-UHFFFAOYSA-N Safety Information Hazard Codes Xi Safety Phrases 26-36 WGK Germany 3 HS Code 2933990090 Synthetic Route Total: 1 Page 5-METHOXY-3-(1-... CAS#:111963-87-2 CAS#:57477-39-1 Literature: Eli Lilly and Company Patent: US6358972 B1, 2002 ; US 6358972 B1 CAS#:1953-54-4 CAS#:57477-39-1 Literature: Medicinal Chemistry Research, , vol. 5, # 9 p. 680 - 689 Precursor & DownStream Precursor 2 CAS#:111963-87-2 5-METHOXY-3-(1-... CAS#:1953-54-4 DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Pharmaceutical Intermediates | ||
|---|---|---|
| N-(3-Indolylacetyl)-L-valine | 57105-42-7 | 2A-9044762 |
| N-(3-Indolylacetyl)-L-isoleucine | 57105-45-0 | 2A-9044763 |
| (S)-1-(4-Nitrophenyl)ethylamine hydrochloride | 57233-86-0 | 2A-9044785 |
| N-Boc-gamma-aminobutyric acid | 57294-38-9 | 2A-9044803 |
| 4-(3-Indolyl)-1-(2-phthalimidoethyl)piperidine | 57311-64-5 | 2A-9044805 |
| (R)-Amino-(4-hydroxyphenyl)acetic acid methyl ester hydrochloride | 57591-61-4 | 2A-9044869 |
| (2-Pyrrolidinyl)methylamine | 57734-57-3 | 2A-9044890 |
| 3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester) | 57757-57-0 | 2A-9044893 |
| 2-Chloromethylimidazo[1,2-a]pyridine hydrochloride | 57892-76-9 | 2A-9044924 |
| Potassium (R)-((3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino)(4-hydroxyphenyl)acetate | 57938-86-0 | 2A-9044929 |
| Browse all Pharmaceutical Intermediates products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS