| Chemical & Physical Properties | |
|---|---|
| CAS Number | 55750-53-3 |
| Catalog No. | 2A-9044480 |
| Chinese Name | 6-马来酰亚氨基己酸 |
| Synonyms | 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid; MFCD00043140; 6-(2,5-dioxopyrrol-1-yl)hexanoic acid |
| Molecular Formula | C10H13NO4 |
| Molecular Weight | 211.21 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 407.3±28.0 °C at 760 mmHg |
| Melting Point | 86-91ºC |
| Storage Condition | 2-8°C |
| Application | 6-Maleimidocapronic acid is a PROTAC linker, belonging to the alkyl chain class. Can be used to synthesize PROTAC molecules. |
| HTC | 2925190090 |
| PubChem ID | 329759803 |
| SMILES | O=C(O)CCCCCN1C(=O)C=CC1=O |
| InChI | InChI=1S/C10H13NO4/c12-8-5-6-9(13)11(8)7-3-1-2-4-10(14)15/h5-6H,1-4,7H2,(H,14,15) |
| InChI Key | WOJKKJKETHYEAC-UHFFFAOYSA-N |
| Bioactivity | 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 407.3±28.0 °C at 760 mmHg Melting Point 86-91ºC Molecular Formula C10H13NO4 Molecular Weight 211.214 Flash Point 200.1±24.0 °C Exact Mass 211.084457 PSA 74.68000 LogP 0.71 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.537 InChIKey WOJKKJKETHYEAC-UHFFFAOYSA-N SMILES O=C(O)CCCCCN1C(=O)C=CC1=O Storage condition 2-8°C |
| Use of | 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Articles78 Name 6-Maleimidocaproic Acid Synonym More Synonyms 6-Maleimidocapronic acid Biological Activity Description 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C10H13NO4 Exact Mass 211.084457 PSA 74.68000 Index of Refraction 1.537 InChIKey WOJKKJKETHYEAC-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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