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Sucralfate structure, CAS 54182-58-0

Sucralfate

CAS Number54182-58-0

SynonymsVenter; Urbal; Sucrate; Succosa; Keal; Citogel; ulcerban; carafate; Ulcar; Sugast

Molecular FormulaC12H14Al16O75S8

Molecular Weight2046.42

Purity98.00%

Density

Boiling Point

Melting Point

Flash Point

Appearancepowder

EINECS259-018-4

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9044145 Purity: 98.00%
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Quality Control of [ 54182-58-0 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number54182-58-0
Catalog No.2A-9044145
Chinese Name硫糖铝
SynonymsVenter; Urbal; Sucrate; Succosa; Keal; Citogel; ulcerban; carafate; Ulcar; Sugast
Molecular FormulaC12H14Al16O75S8
Molecular Weight2046.42
Purity98.00
Appearancepowder
Water SolubilityPractically insoluble in water, in ethanol (96 per
Storage Condition2-8°C
ApplicationSucralfate is a cytoprotective agent that has been used to prevent and treat a variety of gastrointestinal diseases.
EINECS259-018-4
HTC29400090
PubChem ID329824435
SMILESO[Al+]O.O[Al+]O.O[Al+]O.O[Al+]O.O[Al+]O.O[Al+]O.O[Al+]O.O[Al+]O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.[O-]S(=O)(=O)OC[C@H]1O[C@@H](O[C@]2(COS([O-])(=O)=O)O[C@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
InChI1S/C11H20O35S8.16Al.40H2O/c12-47(13,14)36-1-3-4(41-49(18,19)20)5(42-50(21,22)23)6(43-51(24,25)26)9(38-3)39-11(2-37-48(15,16)17)8(45-53(30,31)32)7(44-52(27,28)29)10(40-11)46-54(33,34)35;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h3-10H,1-2H2,(H,12,13,14)(H,15,16,17)(H,18,19,20)(H,21,22,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35);;;;;;;;;;;;;;;;;40*1H2/q;16*+3;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/p-48/t3-,4-,5+,6-,7+,8+,9+,10-,11-;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1......................................................../s1
InChI KeyJTZPPHUZZDKEOC-RBQAPOGLSA-A
NACRES CodeNA.25
UNSPSC12352201
MSDSmsds/44145_1_54182_58_0.pdf
BioactivitySucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Infection In Vivo Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Enemas containing Sucralfate improves the inflammation and increases the tissue contents of neutral and acid mucins. The content of neutral mucins does not change with the time or concentration of Sucralfate used, while acid mucins increases with concentration and time of intervention. A significant increase in tissue content of neutral mucins in animals subjected to irrigation with Sucralfate (SCF) is found compare to animals irrigated with S.F. 0.9%, regardless of the concentration and duration of intervention[1]. Animal Admin Thirty-six male Wistar rats (300 to 350 g) are used in this study. The animals are divided into two experimental groups with 18 animals in each group. Each experimental group is divided into six subgroups (n=6) according to the intervention solution employed and time of intervention. In the first and second subgroups, 12 animals receive daily rectal enemas containing 40 mL of 0.9% saline solution (control subgroup) at 37°C for two weeks (n=6) and four weeks (n=6). In the second subgroup, 12 animals receive daily rectal enemas containing 40 mL of Sucralfate (SCF) at a concentration of 1.0 g/kg for two weeks (n=6) and four weeks (n=6). Finally, 12 animals of the third subgroup receive daily enemas containing 40 mL of Sucralfate at a concentration of 2.0 g/kg for two weeks (n=6) and four weeks (n=6). In order to standardize the speed and time of application, the enemas are administered in all animals with an infusion pump whose speed is standardized at 2/mL/min[1]. References [1]. Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52. Chemical & Physical Properties Molecular Formula C12H14Al16O75S8 Molecular Weight 2046.42 PSA 1435.37000 Storage condition 2-8°C Water Solubility Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
Use ofSucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Properties Articles46 Name Sucralfate Synonym More Synonyms Sucralfate Biological Activity Description Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Infection In Vivo Sucralfate is a cytoprotective agent which has been employed for prevention and treatment of several gastrointestinal diseases. Enemas containing Sucralfate improves the inflammation and increases the tissue contents of neutral and acid mucins. The content of neutral mucins does not change with the time or concentration of Sucralfate used, while acid mucins increases with concentration and time of intervention. A significant increase in tissue content of neutral mucins in animals subjected to irrigation with Sucralfate (SCF) is found compare to animals irrigated with S.F. 0.9%, regardless of the concentration and duration of intervention[1]. References [1]. Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52. Chemical & Physical Properties Molecular Formula C12H14Al16O75S8 PSA 1435.37000 Water Solubility Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
Transport InfoProduct Name: Sucralfate
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