CAS Number51781-06-7
SynonymsCarteololum; Carteolol [INN:BAN]; Carteololum [INN-Latin]; 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one; CARTEOLOL; Ocupress; Carteolol HCl; Carteolol Monohydrochloride; Carteolol (INN); 5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinolin-2-one; 5-[3-(1,1-dimethylethyl)amino-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone
Molecular FormulaC16H25O3N2Cl1
Molecular Weight328.84
Purity98.00%
Density1.13 g/cm3
Boiling Point518.6ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 51781-06-7 |
| Catalog No. | 2A-9043588 |
| Chinese Name | 卡替洛尔 |
| Synonyms | Carteololum; Carteolol [INN:BAN]; Carteololum [INN-Latin]; 5-[3-(tert-Butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one; CARTEOLOL; Ocupress; Carteolol HCl; Carteolol Monohydrochloride; Carteolol (INN); 5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-1H-quinolin-2-one; 5-[3-(1,1-dimethylethyl)amino-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone |
| Molecular Formula | C16H25O3N2Cl1 |
| Molecular Weight | 328.84 |
| Purity | 98.00 |
| Density | 1.13 g/cm3 |
| Boiling Point | 518.6ºC at 760 mmHg |
| Storage Condition | Warehouse low temperature ventilation and drying |
| Application | Catrolol is a non-selective beta-adrenergic receptor antagonist. Catrolol induces apoptosis through caspase activation and mitochondria-dependent pathways. Catrolol can be used in glaucoma research [1 |
| HTC | 2933790090 |
| PubChem ID | 9091 |
| MDL Number | MFCD00941499 |
| SMILES | CC(C)(C)NCC(O)COc1cccc2c1CCC(=O)N2 |
| InChI | InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20) |
| InChI Key | LWAFSWPYPHEXKX-UHFFFAOYSA-N |
| MSDS | msds/43588_1_51781_06_7.pdf |
| Use of | Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1]. Properties Name carteolol Synonym More Synonyms Carteolol Biological Activity Description Carteolol is a non-selective β-adrenoceptor antagonist. Carteolol induces apoptosis via a caspase activated and mitochondrial-dependent pathway. Carteolol can be used for glaucoma research[1]. Related Catalog Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease In Vitro Carteolol (0-2%; 0-28 hours; HCECs) has cytotoxicity and decreases cell viability in a dose- and time-dependent manner[1]. Carteolol (0.25%; 4-12 hours; HCECs) induces apoptosis and necroptotic protein expression in HCECs[1]. Cell Viability Assay[1] Cell Line: HCECs Concentration: 0.00390625-2% Incubation Time: 0, 2, 4, 8, 16, 20,24 and 28 hours Result: Decreased cell viability with the concentrations above 0.0015625% in a dose- and time-dependent manner. Western Blot Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Dampened expression of the anti-apoptotic protein Bcl-2 and Bcl-xL, enhanced expression of the pro-apoptotic proteins Bax and Bad, and mitochondrial-released pro-apoptotic proteins Cyt.c and AIF. Cell Cycle Analysis[1] Cell Line: HCECs Concentration: 0.25% Incubation Time: 4, 8 and 12 hours Result: Increased the number of G1 phase of the cell cycle, whereas decreased S phase. References [1]. Su W, et, al. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020 Mar 6;11:202. Chemical & Physical Properties Molecular Formula C16H24N2O3 Exact Mass 292.17900 PSA 70.59000 LogP 2.22800 Index of Refraction 1.5800 (estimate) InChIKey LWAFSWPYPHEXKX-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2(1H)-Quinolinone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4 -dihydro- CAS REGISTRY NUMBER : 51781-06-7 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H24-N2-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T66 BMVT&J GO1YQ1MX1&1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,323,1980 Safety Information HS Code 2933790090 Synthetic Route Total: 1 Page Carteolol (hydr... CAS#:51781-21-6 CAS#:51781-06-7 Literature: Spataro, Gregory; Malecaze, Francois; Turrin, Cedric-Olivier; Soler, Vincent; Duhayon, Carine; Elena, Pierre-Paul; Majoral, Jean-Pierre; Caminade, Anne-Marie European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 326 - 334 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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