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(Z)-Guggulsterone structure, CAS 39025-23-5

(Z)-Guggulsterone

CAS Number39025-23-5

SynonymsGuggulsterone; (17E)-Pregna-4,17-diene-3,16-dione; (17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione; UNII:9B259YE66O; (17E)-Pregna-4,17(20)-diene-3,16-dione; Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione; E-guggulsterone; trans-Guggulsterone

Molecular FormulaC21H28O2

Molecular Weight312.45

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point463.3±45.0 °C at 760 mmHg

Melting Point188-190°

Flash Point

Appearance

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Cat. No.: 2A-9042249 Purity: 98.00%
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Quality Control of [ 39025-23-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number39025-23-5
Catalog No.2A-9042249
Chinese Name固甾酮
SynonymsGuggulsterone; (17E)-Pregna-4,17-diene-3,16-dione; (17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione; UNII:9B259YE66O; (17E)-Pregna-4,17(20)-diene-3,16-dione; Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione; E-guggulsterone; trans-Guggulsterone
Molecular FormulaC21H28O2
Molecular Weight312.45
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point463.3±45.0 °C at 760 mmHg
Melting Point188-190°
Storage Condition2-8°C
ApplicationZ-guggulsterone, a component of the Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by
PubChem ID11972063
MDL NumberC21H28O2
SMILESCC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C
InChIInChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
InChI KeyWDXRGPWQVHZTQJ-OSJVMJFVSA-N
Hazard Symbolstransportation
MSDSmsds/42249_1_39025_23_5.pdf
BioactivityZ-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Target VEGF-R2 Akt In Vitro Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC. In Vivo Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1]. Animal Model: Male nude mice (5-6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage: 1 mg Administration: Oral; 5 times/week Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight. References [1]. Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 463.3±45.0 °C at 760 mmHg Melting Point 188-190° Molecular Formula C21H28O2 Molecular Weight 312.446 Flash Point 172.3±25.7 °C Exact Mass 312.208923 PSA 34.14000 LogP 3.65 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.557 InChIKey WDXRGPWQVHZTQJ-OSJVMJFVSA-N SMILES CC=C1C(=O)CC2C3CCC4=CC(=O)CCC4(C)C3CCC12C Storage condition 2-8°C
Use ofZ-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis[1]. Properties Articles33 Name (Z)-Guggulsterone Synonym More Synonyms Z-Guggulsterone Biological Activity Description Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR In Vitro Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC. References [1]. Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80. Chemical & Physical Properties Molecular Formula C21H28O2 Exact Mass 312.208923 PSA 34.14000 Index of Refraction 1.557 InChIKey WDXRGPWQVHZTQJ-OSJVMJFVSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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