CAS Number20324-87-2
Synonyms2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2); Disodium 4-hydroxy-7-{[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoyl]amino}naphthalene-2-sulfonate; Disodium 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonate); AMI-1
Molecular FormulaC21H14N2Na2O9S2
Molecular Weight504.49 (anhydrous free acid basis)
Purity≥98 (HPLC)%
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20324-87-2 |
| Catalog No. | 2A-9038376 |
| Chinese Name | 6,6'-(1,3-亚脲基)双(1-萘酚-3-磺酸钠) |
| Synonyms | 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis[4-hydroxy-, sodium salt (1:2); Disodium 4-hydroxy-7-{[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoyl]amino}naphthalene-2-sulfonate; Disodium 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonate); AMI-1 |
| Molecular Formula | C21H14N2Na2O9S2 |
| Molecular Weight | 504.49 (anhydrous free acid basis) |
| Purity | ≥98 (HPLC) |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | AMI-1 is a potent cell-permeable inhibitor of protein arginine N-methyltransferases (PRMTs), inhibiting human PRMT1 (IC50 =8.8μM) and yeast Hmt1p (IC50 =3.0μM). |
| HTC | 2924299090 |
| SMILES | O=C(Nc1ccc2c(O)cc(S(=O)(=O)[O-])cc2c1)Nc1ccc2c(O)cc(S(=O)(=O)[O-])cc2c1.[Na+].[Na+] |
| InChI | InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2 |
| InChI Key | MOUNHKKCIGVIDI-UHFFFAOYSA-L |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/38376_1_20324_87_2.pdf |
| Use of | Properties Name Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Synonym More Synonyms AMI 1 Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer References [1]. Sun Q, et al. PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation. J Immunol. 2015 Jul 1;195(1):298-306. [2]. Castellano S, et al. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 1;5(3):398-414. [4]. Wang J, et al. Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation. J Med Chem. 2012 Sep 27;55(18):7978-7987. Chemical & Physical Properties Molecular Formula C21H14N2Na2O9S2 Exact Mass 547.993591 PSA 212.75000 LogP 5.16400 InChIKey MOUNHKKCIGVIDI-UHFFFAOYSA-L Storage condition -20℃ Safety Information HS Code 2924299090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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