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Oxybuprocaine hydrochloride structure, CAS 5987-82-6

Oxybuprocaine hydrochloride

CAS Number5987-82-6

SynonymsBenzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride (1:1); Oxybuprocaine HCL; 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate,hydrochloride; Benoxinate hydrochloride; 2-(Diethylamino)ethyl-4-amino-3-butoxybenzolcarboxylathydrochlorid; MFCD00012512; EINECS 227-808-8; oxybuprocaine hydrochloride

Molecular FormulaC17H29ClN2O3

Molecular Weight344.88

Purity98.00%

Density

Boiling Point446.9ºC at 760 mmHg

Melting Point158 - 162ºC

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9032376 Purity: 98.00%
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Quality Control of [ 5987-82-6 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5987-82-6
Catalog No.2A-9032376
Chinese Name盐酸奥布卡因
SynonymsBenzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1); 2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride (1:1); Oxybuprocaine HCL; 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate,hydrochloride; Benoxinate hydrochloride; 2-(Diethylamino)ethyl-4-amino-3-butoxybenzolcarboxylathydrochlorid; MFCD00012512; EINECS 227-808-8; oxybuprocaine hydrochloride
Molecular FormulaC17H29ClN2O3
Molecular Weight344.88
Purity98.00
Boiling Point446.9ºC at 760 mmHg
Melting Point158 - 162ºC
Appearancesolid
Storage ConditionAvoid light, keep in a cool and dry place, sealed
ApplicationOxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents the transmission of impulses from pain nerves in the cornea, conjunctiva and sclera. Oxybuprocaine
HTC29225000
MDL NumberMFCD00012512
SMILESCl[H].CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC
InChI1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H
InChI KeyPRGUDWLMFLCODA-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/32376_1_5987_82_6.pdf
Use ofOxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3]. Properties Articles17 Name oxybuprocaine hydrochloride Synonym More Synonyms benoxinate hydrochloride Biological Activity Description Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Chen YW, et al. The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):601-6. [2]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018 May;126(5):1721-1728. [3]. Page M, et al. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topicalocular anesthetic for use in ophthalmic procedures. Clin Ophthalmol. 2009;3:601-9. Epub 2009 Nov 2. Chemical & Physical Properties Exact Mass 344.186676 PSA 64.79000 LogP 4.32950 InChIKey PRGUDWLMFLCODA-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, monohydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : 4OR BZ EVO2N2&2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 5600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1957,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 4200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990 Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P305 + P351 + P338 Hazard Codes Xi Safety Phrases S22-S26-S36 RTECS DG15029 HS Code 29225000
Transport InfoProduct name: Oxybucaine hydrochloride
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