| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5967-84-0 |
| Catalog No. | 2A-9032358 |
| Chinese Name | 茶碱一水合物 |
| Synonyms | EINECS 200-385-7; MFCD00151659; Theophylline monohydrate |
| Molecular Formula | C7H10O3N4 |
| Molecular Weight | 198.18 |
| Purity | 98.00 |
| Boiling Point | 454.1ºC at 760 mmHg |
| Melting Point | 270-274°C |
| Storage Condition | Store at room temperature, away from light, in a c |
| Application | Theophylline (1,3-dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-dimethylxanthi |
| HTC | 2933990090 |
| MDL Number | MFCD00151659 |
| SMILES | Cn1c(=O)c2[nH]cnc2n(C)c1=O.O |
| InChI | InChI=1S/C7H8N4O2.H2O/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;/h3H,1-2H3,(H,8,9);1H2 |
| InChI Key | INQSMEFCAIHTJG-UHFFFAOYSA-N |
| MSDS | msds/32358_1_5967_84_0.pdf |
| Use of | Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. Properties Name Theophylline Monohydrate Synonym More Synonyms Theophylline monohydrate Biological Activity Description Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Signaling Pathways >> Epigenetics >> HDAC Human Endogenous Metabolite References [1]. Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. [2]. Chung IY, et, al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000 Aug 1;203(2):95-102. [3]. Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):558-61. [4]. Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. [5]. Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. Chemical & Physical Properties Molecular Formula C7H10N4O3 Exact Mass 198.07500 PSA 81.91000 InChIKey INQSMEFCAIHTJG-UHFFFAOYSA-N Safety Information RIDADR 2811 HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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