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Beclomethasone dipropionate structure, CAS 5534-09-8

Beclomethasone dipropionate

CAS Number5534-09-8

Synonyms9-Chloro-16-β-methyl-11-β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-Dipropionate; Viarex; Beconasol; Becloval; (11b,16b)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione; Becodisks; Anceron; Vancenase AQ; (11b,16b)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate; (11β,16β)-9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate; EINECS 226-886-0; Beclomethasone dipropionate (USP); Beclomethasone dipropionate; Andion; MFCD00135613; 9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-Dipropionate; Beclometasone dipropionate

Molecular FormulaC28H37ClO7

Molecular Weight521.04

Purity98.00%

Density1.3±0.1 g/cm3

Boiling Point630.5±55.0 °C at 760 mmHg

Melting Point210ºC

Flash Point

AppearanceWhite crystalline powder

EINECS226-886-0

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9031952 Purity: 98.00%
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Quality Control of [ 5534-09-8 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number5534-09-8
Catalog No.2A-9031952
Chinese Name丙酸倍氯米松
Synonyms9-Chloro-16-β-methyl-11-β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-Dipropionate; Viarex; Beconasol; Becloval; (11b,16b)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione; Becodisks; Anceron; Vancenase AQ; (11b,16b)-9-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate; (11β,16β)-9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate; EINECS 226-886-0; Beclomethasone dipropionate (USP); Beclomethasone dipropionate; Andion; MFCD00135613; 9-Chloro-11b-hydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-Dipropionate; Beclometasone dipropionate
Molecular FormulaC28H37ClO7
Molecular Weight521.04
Purity98.00
Density1.3±0.1 g/cm3
Boiling Point630.5±55.0 °C at 760 mmHg
Melting Point210ºC
AppearanceWhite crystalline powder
Storage ConditionStore at 2-8℃ away from light, in a cool and dry p
ApplicationBeclometasone dipropionate is a glucocorticoid agonist and is the original drug of the free form of beclometasone.
EINECS226-886-0
HTC2937290090
PubChem ID329823513
MDL NumberMFCD00135613
SMILESCCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C
InChI1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
InChI KeyKUVIULQEHSCUHY-XYWKZLDCSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/31952_1_5534_09_8.pdf
BioactivityBeclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone. IC50 Value: 0.2 nM (Inhibiting thymidine incorporation) [1]Target: glucocorticoid receptorin vitro: Cortisol and beclomethasone dipropionate were more potent than salbutamol in inhibiting thymidine incorporation with IC50 values of 5 nM and 0.2 nM respectively. Cortisol 100 nM led to a 16.6 ± 6.5% reduction and beclomethasone dipropionate 3 nM led to a 17.8 ± 5.8% reduction in cell number [1]. in vivo: Controlled trials involving 497 adults and children demonstrated similar clinical efficacy between nebulized BDP and either nebulized fluticasone propionate or nebulized budesonide. Meta-analyses show that BDP, like other inhaled corticosteroids, has no major influence on patient height, urinary cortisol concentration, or bone metabolism [2]. Beclometasone dipropionate (BDP) 800 microgday(-1) suspension for nebulization and budesonide (BUD) 750 microg day(-1) given by nebulization in a twice-daily regimen, and when used in addition to the usual maintenance therapy, resulted in comparable clinical efficacy across all parameters [3]. Clinical trial: Efficacy and Tolerability of Beclometasone/Formoterol Single Inhaler in Patients With Moderate to Severe Persistent Asthma. Phase 3 Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995 Jan 24;273(1-2):137-43. [2]. Nicolini G, Cremonesi G, Melani AS. Inhaled corticosteroid therapy with nebulized beclometasone dipropionate. Pulm Pharmacol Ther. 2010 Jun;23(3):145-55. [3]. Delacourt C, et al. Comparison of the efficacy and safety of nebulized beclometasone dipropionate and budesonide in severe persistent childhood asthma. Respir Med. 2003 Feb;97 Suppl B:S27-33. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 630.5±55.0 °C at 760 mmHg Melting Point 210ºC Molecular Formula C28H37ClO7 Molecular Weight 521.042 Flash Point 335.1±31.5 °C Exact Mass 520.222778 PSA 106.97000 LogP 4.59 Vapour Pressure 0.0±4.2 mmHg at 25°C Index of Refraction 1.564 InChIKey KUVIULQEHSCUHY-KLRSCUJKSA-N SMILES CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC21C
Use ofProperties Articles48 Name beclomethasone dipropionate Synonym More Synonyms Beclometasone dipropionate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Research Areas >> Inflammation/Immunology References [1]. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995 Jan 24;273(1-2):137-43. [2]. Nicolini G, Cremonesi G, Melani AS. Inhaled corticosteroid therapy with nebulized beclometasone dipropionate. Pulm Pharmacol Ther. 2010 Jun;23(3):145-55. [3]. Delacourt C, et al. Comparison of the efficacy and safety of nebulized beclometasone dipropionate and budesonide in severe persistent childhood asthma. Respir Med. 2003 Feb;97 Suppl B:S27-33. Chemical & Physical Properties Exact Mass 520.222778 PSA 106.97000 Index of Refraction 1.564 InChIKey KUVIULQEHSCUHY-KLRSCUJKSA-N
Transport InfoProduct name: Beclomethasone dipropionate
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