CAS Number5957-80-2
Synonyms(7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one; (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one; Carnosol
Molecular FormulaC20H26O4
Molecular Weight330.42
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point524.8±50.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5957-80-2 |
| Catalog No. | 2A-9032348 |
| Chinese Name | 鼠尾草酚 |
| Synonyms | (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one; (7β)-11,12-Dihydroxy-7,20-epoxyabieta-8(14),9(11),12-trien-20-one; Carnosol |
| Molecular Formula | C20H26O4 |
| Molecular Weight | 330.42 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 524.8±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ Avoid light, keep in a cool and dry place, se |
| Application | Carnosol is a potent ribosomal S6 kinase (RSK2) inhibitor for the treatment of gastric cancer with an IC50 value of approximately 5.5 μM. |
| PubChem ID | 329775081 |
| MDL Number | MFCD02752467 |
| SMILES | CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O |
| InChI | 1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 |
| InChI Key | XUSYGBPHQBWGAD-PJSUUKDQSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/32348_1_5957_80_2.pdf |
| Bioactivity | Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Natural Products >> Phenols Research Areas >> Cancer Target IC50: 5.5 μM (RSK2)[1]. In Vitro It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1[1]. In Vivo Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1]. Animal Admin Mice[1] Mice are orally administrated Carnosol at 100 mg/kg or vehicle 5 times a week over a period of 31 days[1]. References [1]. Wang L, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018 Feb 6;9(76):34200-34212. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 524.8±50.0 °C at 760 mmHg Molecular Formula C20H26O4 Molecular Weight 330.418 Flash Point 187.0±23.6 °C Exact Mass 330.183105 PSA 66.76000 LogP 3.71 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.607 InChIKey XUSYGBPHQBWGAD-PJSUUKDQSA-N SMILES CC(C)c1cc2c(c(O)c1O)C13CCCC(C)(C)C1CC2OC3=O Storage condition −20°C |
| Use of | Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Properties Articles28 Name carnosol Synonym More Synonyms Carnosol Biological Activity Description Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK) Natural Products >> Phenols Research Areas >> Cancer IC50: 5.5 μM (RSK2)[1]. In Vivo Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1]. References [1]. Wang L, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018 Feb 6;9(76):34200-34212. Chemical & Physical Properties Molecular Formula C20H26O4 Exact Mass 330.183105 PSA 66.76000 Index of Refraction 1.607 InChIKey XUSYGBPHQBWGAD-PJSUUKDQSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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