CAS Number5577-13-9
SynonymsTosylcarbamic acid ethyl ester; Ethyl [(4-methylphenyl)sulfonyl]carbamate; ethyl N-(4-toluenesulfonyl)carbamate; ethyl tosylcarbaMate; Ethyl [(4-methylphenyl)sulphonyl]carbamate; Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester; Tosylurethane; ethoxycarbonamide of p-toluenebenzenesulfoacid; ethyl p-tosylcarbamate; (toluene-4-sulfonyl)-carbamic acid ethyl ester; ethyl N-(tosyl)carbamate; Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester; N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester; 2OVMSWR D1; N-(p-Tolylsulfonyl)carbamic acid ethyl ester
Molecular FormulaC10H13O4N1S1
Molecular Weight243.28
Purity98.00%
Density1.3±0.1 g/cm3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5577-13-9 |
| Catalog No. | 2A-9031982 |
| Chinese Name | N-(4-甲基苯基)磺酰氨基甲酸乙酯 |
| Synonyms | Tosylcarbamic acid ethyl ester; Ethyl [(4-methylphenyl)sulfonyl]carbamate; ethyl N-(4-toluenesulfonyl)carbamate; ethyl tosylcarbaMate; Ethyl [(4-methylphenyl)sulphonyl]carbamate; Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester; Tosylurethane; ethoxycarbonamide of p-toluenebenzenesulfoacid; ethyl p-tosylcarbamate; (toluene-4-sulfonyl)-carbamic acid ethyl ester; ethyl N-(tosyl)carbamate; Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester; N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester; 2OVMSWR D1; N-(p-Tolylsulfonyl)carbamic acid ethyl ester |
| Molecular Formula | C10H13O4N1S1 |
| Molecular Weight | 243.28 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Storage Condition | room temperature, dry |
| Application | Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). Gliclazide is a whole-cell β-cell ATP-sensitive potassium current blocker with an IC50 of 184 nM. |
| HTC | 2935009090 |
| MDL Number | MFCD00797861 |
| SMILES | CCOC(=O)NS(=O)(=O)c1ccc(C)cc1 |
| InChI | InChI=1S/C10H13NO4S/c1-3-15-10(12)11-16(13,14)9-6-4-8(2)5-7-9/h4-7H,3H2,1-2H3,(H,11,12) |
| InChI Key | DFWQXANLGSXMKF-UHFFFAOYSA-N |
| MSDS | msds/31982_1_5577_13_9.pdf |
| Use of | Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3]. Properties Name Ethyl N-(4-methylphenyl)sulfonylcarbamate Synonym More Synonyms Biological Activity Description Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877)[1][2]. Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM[3]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel References [1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27. [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476-1478. Chemical & Physical Properties Molecular Formula C10H13NO4S Exact Mass 243.056534 PSA 80.85000 Index of Refraction 1.530 InChIKey DFWQXANLGSXMKF-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2935009090 Synthetic Route Ethyl chloroformate CAS#:541-41-3 4-Toluenesulfonamide CAS#:70-55-3 Ethyl [(4-methy... CAS#:5577-13-9 Literature: Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546 p-Toluenesulfon... CAS#:4083-64-1 Ethyl [(4-methy... CAS#:5577-13-9 Literature: US5326796 A1, ; 1,3-bis-(4-meth... CAS#:5219-81-8 Ethyl carbonate CAS#:105-58-8 Ethyl [(4-methy... CAS#:5577-13-9 Literature: Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111 Precursor & DownStream Precursor 7 CAS#:541-41-3 Ethyl chloroformate CAS#:70-55-3 4-Toluenesulfonamide CAS#:4083-64-1 p-Toluenesulfon... CAS#:5219-81-8 1,3-bis-(4-meth... DownStream 7 CAS#:4083-64-1 p-Toluenesulfon... CAS#:28490-28-0 3-Pentenamide,4... CAS#:28490-61-1 2-Butenamide,3-... CAS#:28490-23-5 Benzenesulfonam... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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