CAS Number4547-24-4
Synonyms2-a-hydroxyursolic acid; hydroxyursolic acid; Corosolic acid; 2,3-dihydroxyurs-12-en-28-oic acid; 2alpha-hydroxyursolic acid; 2α-Hydroxyursolic acid; MFCD03840521; (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid
Molecular FormulaC30H48O4
Molecular Weight472.70
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point573.3±50.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4547-24-4 |
| Catalog No. | 2A-9031017 |
| Chinese Name | 科罗索酸 |
| Synonyms | 2-a-hydroxyursolic acid; hydroxyursolic acid; Corosolic acid; 2,3-dihydroxyurs-12-en-28-oic acid; 2alpha-hydroxyursolic acid; 2α-Hydroxyursolic acid; MFCD03840521; (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.70 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 573.3±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Corosolic acid is a natural compound reported to have anti-tumor activity. |
| PubChem ID | 329799816 |
| MDL Number | MFCD06794973 |
| SMILES | O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1 |
| InChI | 1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1 |
| InChI Key | HFGSQOYIOKBQOW-ZSDYHTTISA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352106 |
| MSDS | msds/31017_1_4547_24_4.pdf |
| Bioactivity | Corosolic acid isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity.IC50 value: 26.8 μg/ml in vitroTarget:In vitro: Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay [1]. MTT method was used to detect the influence of corosolic acid on A549 lung cancer cell growth in vitro under different concentrations. The value of IC50 was 26.8 μg/ml in vitro experiment. Corosolic acid of different doses had certain therapeutic effects on A549 solid tumor, the content of VEGF and CD34 proteins also had different degrees of influence [2]. Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. It inhibited the proliferation and tube formation of human umbilical vein endothelial cells and human dermal lymphatic microvascular endothelial cells, decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1 [3]. In vivo: A mouse colon carcinoma CT-26 animal model was employed to determine the in vivo anti-angiogenic and anti-lymphangiogenic effects of corosolic acid. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Terpenoids and Glycosides References [1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70. [2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08 [3]. Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14-723 Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 573.3±50.0 °C at 760 mmHg Molecular Formula C30H48O4 Molecular Weight 472.700 Flash Point 314.6±26.6 °C Exact Mass 472.355255 PSA 77.76000 LogP 7.82 Vapour Pressure 0.0±3.6 mmHg at 25°C Index of Refraction 1.567 InChIKey HFGSQOYIOKBQOW-ZSDYHTTISA-N SMILES CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1C Storage condition 2-8°C |
| Use of | Properties Articles29 Name Corosolic acid Synonym More Synonyms Corosolic acid Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer Natural Products >> Terpenoids and Glycosides References [1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70. [2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08 Chemical & Physical Properties Molecular Formula C30H48O4 Exact Mass 472.355255 PSA 77.76000 Index of Refraction 1.567 InChIKey HFGSQOYIOKBQOW-ZSDYHTTISA-N |
| Transport Info | Product name: Corosolic acid |
| Related Products in Botanical Reference Standards | ||
|---|---|---|
| Oleanolic acid 3-acetate | 4339-72-4 | 2A-9030785 |
| Maslinic acid | 4373-41-5 | 2A-9030816 |
| 1,4-Bis[(2-hydroxyethyl)amino]anthraquinone | 4471-41-4 | 2A-9030941 |
| DL-Sulforaphane | 4478-93-7 | 2A-9030949 |
| Betulonic acid | 4481-62-3 | 2A-9030951 |
| Phenyl beta-D-galactopyranoside | 4630-62-0 | 2A-9031082 |
| 4-Bromostilbene | 4714-24-3 | 2A-9031135 |
| Succinyl oleanolic acid | 4847-30-7 | 2A-9031261 |
| Aristolochic acid C | 4849-90-5 | 2A-9031263 |
| Procyanidin | 4852-22-6 | 2A-9031265 |
| Browse all Botanical Reference Standards products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS