CAS Number2140-72-9
Synonyms2'-OMe Cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one; 2'-OMeCytidine; 2'-O-Methyl-D-cytidine; 2'-O-Methyl Cytidine; O2'-methylcytidine; 4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one; 4-Amino-1-(2-O-methyl-β-D-ribofuranosyl)pyrimidin-2(1H)-on; 2'-OMe-C; 2'-O-methyl-2'-deoxy-cytidine; 2′-O-methylcytidine; MFCD00056067; 2'-O-Methylcytidine; 2'-O-Methylcytidine; 2'-O-methyl-cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one; 2'-O-(TERT-BUTYLDIMETHYLSILYL)-6A-HYDROXY-7-EPI-PACLITAXEL
Molecular FormulaC10H15N3O5
Molecular Weight257.243
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point506.0±60.0 °C at 760 mmHg
Melting Point252-253ºC
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2140-72-9 |
| Catalog No. | 2A-9028038 |
| Chinese Name | 2'-甲氧基胞苷 |
| Synonyms | 2'-OMe Cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one; 2'-OMeCytidine; 2'-O-Methyl-D-cytidine; 2'-O-Methyl Cytidine; O2'-methylcytidine; 4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one; 4-Amino-1-(2-O-methyl-β-D-ribofuranosyl)pyrimidin-2(1H)-on; 2'-OMe-C; 2'-O-methyl-2'-deoxy-cytidine; 2′-O-methylcytidine; MFCD00056067; 2'-O-Methylcytidine; 2'-O-Methylcytidine; 2'-O-methyl-cytidine; 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one; 2'-O-(TERT-BUTYLDIMETHYLSILYL)-6A-HYDROXY-7-EPI-PACLITAXEL |
| Molecular Formula | C10H15N3O5 |
| Molecular Weight | 257.243 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 506.0±60.0 °C at 760 mmHg |
| Melting Point | 252-253ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Water solubility: slightly soluble |
| Storage Condition | −20°C |
| Application | 2'-O-Methylcytidine is a 2'-substituted nucleoside that acts as an inhibitor of HCV replication. 2'-O-methylcytidine inhibits RNA synthesis catalyzed by RNA-dependent RNA polymerase (NS5B) in vitro by |
| HTC | 2934999090 |
| PubChem ID | 801056 |
| SMILES | N2(C=CC(=NC2=O)N)[C@@H]1O[C@@H]([C@H]([C@H]1OC)O)CO |
| InChI | 1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1 |
| InChI Key | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/28038_1_2140_72_9.pdf |
| Bioactivity | 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1]. Related Catalog Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection References [1]. Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84 Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 506.0±60.0 °C at 760 mmHg Melting Point 252-253ºC Molecular Formula C10H15N3O5 Molecular Weight 257.243 Flash Point 259.8±32.9 °C Exact Mass 257.101166 PSA 119.83000 LogP -1.09 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.677 InChIKey RFCQJGFZUQFYRF-ZOQUXTDFSA-N SMILES COC1C(O)C(CO)OC1n1ccc(N)nc1=O Storage condition −20°C |
| Use of | 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1]. Properties Name 2'-O-methylcytidine Synonym More Synonyms 2′-O-methylcytidine Biological Activity Description 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1]. Related Catalog Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection References [1]. Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84 Chemical & Physical Properties Molecular Formula C10H15N3O5 Exact Mass 257.101166 PSA 119.83000 LogP -1.09 Index of Refraction 1.677 InChIKey RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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