CAS Number2140-71-8
Synonyms2'-methylguanosine; Gm19; 2'-O-(TERT-BUTYLDIMETHYLSILYL)PACLITAXEL; UNII-W722H4PA1S; 2'-O-Methylguanosine; Guanosine,2'-O-methyl; 2'-O-Methyl Guanosine; 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one; MFCD00057053; O2'-methyl-guanosine; 2'-O-methyl-guanosine; 2'-OMeGuanosine; 2'-O-Methylguanosine Hydrate
Molecular FormulaC11H15O5N5
Molecular Weight297.27
Purity98.00%
Density2.0±0.1 g/cm3
Boiling Point711.7ºC at 760 mmHg
Melting Point218-220ºC
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2140-71-8 |
| Catalog No. | 2A-9028037 |
| Chinese Name | 2'-甲氧基鸟苷 |
| Synonyms | 2'-methylguanosine; Gm19; 2'-O-(TERT-BUTYLDIMETHYLSILYL)PACLITAXEL; UNII-W722H4PA1S; 2'-O-Methylguanosine; Guanosine,2'-O-methyl; 2'-O-Methyl Guanosine; 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one; MFCD00057053; O2'-methyl-guanosine; 2'-O-methyl-guanosine; 2'-OMeGuanosine; 2'-O-Methylguanosine Hydrate |
| Molecular Formula | C11H15O5N5 |
| Molecular Weight | 297.27 |
| Purity | 98.00 |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 711.7ºC at 760 mmHg |
| Melting Point | 218-220ºC |
| Appearance | white solid |
| Storage Condition | Refrigerator |
| Application | 2'-O-Methylguanosine is a modified nucleoside produced by tRNA guanosine-2'-o-methyltransferase. 2'-O-Methylguanosine has certain pro-apoptotic effects. |
| HTC | 2934999090 |
| PubChem ID | 3718407 |
| MDL Number | MFCD00057053 |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n2cnc3C(=O)N=C(N)Nc23 |
| InChI | InChI=1S/C11H15N5O5/c1-20-7-6(18)4(2-17)21-10(7)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1 |
| InChI Key | InChIKey=OVYNGSFVYRPRCG-KQYNXXCUSA-N |
| MSDS | msds/28037_1_2140_71_8.pdf |
| Bioactivity | 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease References [1]. B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25(20):4093-7. [2]. T Mori, et al. Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line. Biochem Biophys Res Commun. 1998 Oct 20;251(2):416-22. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 711.7ºC at 760 mmHg Melting Point 218-220ºC Molecular Formula C11H15N5O5 Molecular Weight 297.267 Flash Point 384.2ºC Exact Mass 297.107330 PSA 148.51000 LogP -0.36 Vapour Pressure 2.93E-21mmHg at 25°C Index of Refraction 1.829 Storage condition Refrigerator |
| Use of | 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2]. Properties Name 2'-O-methylguanosine Synonym More Synonyms 2'-O-Methylguanosine Biological Activity Description 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2'-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease References [1]. B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25(20):4093-7. [2]. T Mori, et al. Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line. Biochem Biophys Res Commun. 1998 Oct 20;251(2):416-22. Chemical & Physical Properties Molecular Formula C11H15N5O5 Exact Mass 297.107330 PSA 148.51000 LogP -0.36 Index of Refraction 1.829 Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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