CAS Number1135-66-6
Synonyms(1R)-2,2,7,7-Tetramethyltricyclo[6.2.1.01.6]undec-5-ene; EINECS 214-494-2; (1R,8S)-2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene; 2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene; trans-Isolongifolene; 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyI-2H-2,4a-methanonaphthalene; MFCD00042616; iso-Longifolene
Molecular FormulaC15H24
Molecular Weight204.35
Purity≥98.0 (sum of enantiomers, GC)%
Density1.0±0.1 g/cm3
Boiling Point255-256 °C
AppearanceColorless or light yellow liquid
EINECS214-494-2
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1135-66-6 |
| Catalog No. | 2A-9026307 |
| Chinese Name | 异长叶烯 |
| Synonyms | (1R)-2,2,7,7-Tetramethyltricyclo[6.2.1.01.6]undec-5-ene; EINECS 214-494-2; (1R,8S)-2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene; 2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene; trans-Isolongifolene; 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyI-2H-2,4a-methanonaphthalene; MFCD00042616; iso-Longifolene |
| Molecular Formula | C15H24 |
| Molecular Weight | 204.35 |
| Purity | ≥98.0 (sum of enantiomers, GC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 255-256 °C |
| Appearance | Colorless or light yellow liquid |
| Storage Condition | Room temperature, sealed, dry |
| Packaging | III |
| Application | Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene alleviates rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis by |
| EINECS | 214-494-2 |
| HTC | 2902199090 |
| PubChem ID | 57651645 |
| MDL Number | MFCD00042616 |
| SMILES | CC1(C)CCC=C2C(C)(C)[C@H]3CC[C@@]12C3 |
| InChI | 1S/C15H24/c1-13(2)8-5-6-12-14(3,4)11-7-9-15(12,13)10-11/h6,11H,5,7-10H2,1-4H3/t11-,15-/m0/s1 |
| InChI Key | CQUAYTJDLQBXCQ-NHYWBVRUSA-N |
| Beilstein/REAXYS | 2207559 |
| NACRES Code | NA.22 |
| UNSPSC | 12352200 |
| Hazard Symbols | 3.2 |
| MSDS | msds/26307_1_1135_66_6.pdf |
| Bioactivity | Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease In Vitro Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM Incubation Time: 26 hours Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. References [1]. Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 266.5±7.0 °C at 760 mmHg Molecular Formula C15H24 Molecular Weight 204.351 Flash Point 102.6±13.0 °C Exact Mass 204.187805 LogP 6.36 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.518 InChIKey CQUAYTJDLQBXCQ-VPHXOMNUSA-N SMILES CC1(C)C2=CCCC(C)(C)C23CCC1C3 |
| Use of | Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1]. Properties Name Isolongifolene Synonym More Synonyms Isolongifolene Biological Activity Description Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease In Vitro Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM Incubation Time: 26 hours Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. References [1]. Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261. Chemical & Physical Properties Molecular Formula C15H24 Exact Mass 204.187805 Index of Refraction 1.518 InChIKey CQUAYTJDLQBXCQ-VPHXOMNUSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Danger Regulations: 2319 International Maritime Transport Danger Regulations: 2319 International Air Transport Danger Regulations: 2319 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TERPENE HYDROCARBONS, N.O.S. IMDG: TERPENE HYDROCARBONS, N.O.S. IMDG: Terpene hydrocarbons, n.o.s. 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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