CAS Number1134-47-0
Synonyms4-Amino-3-(4-chlorophenyl)butanoic acid; Lioresa; EINECS 214-486-9; (R,S)-Baclofen; b-(Aminomethyl)-4-chlorobenzenepropanoic Acid; baclon; b-(Aminomethyl)-p-chlorohydrocinnamic Acid; Z1YR DG&1VQ; Kemstro; Clofen; Baclofen; MFCD00055143; (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; DL-Baclofen; 4-Amino-3-(4-chlorophenyl)butyric Acid; (±)-Baclofen; Lioresal; Atrofen
Molecular FormulaC10H12ClNO2
Molecular Weight213.66
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point364.3±32.0 °C at 760 mmHg
Melting Point208-210°C
AppearanceWhite to very light yellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1134-47-0 |
| Catalog No. | 2A-9026302 |
| Chinese Name | 巴氯芬 |
| Synonyms | 4-Amino-3-(4-chlorophenyl)butanoic acid; Lioresa; EINECS 214-486-9; (R,S)-Baclofen; b-(Aminomethyl)-4-chlorobenzenepropanoic Acid; baclon; b-(Aminomethyl)-p-chlorohydrocinnamic Acid; Z1YR DG&1VQ; Kemstro; Clofen; Baclofen; MFCD00055143; (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid; DL-Baclofen; 4-Amino-3-(4-chlorophenyl)butyric Acid; (±)-Baclofen; Lioresal; Atrofen |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 364.3±32.0 °C at 760 mmHg |
| Melting Point | 208-210°C |
| Appearance | White to very light yellow solid |
| Water Solubility | 1 M HCl: 50 mg/mL |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Packaging | III |
| Application | Baclofen is a GABA derivative that relaxes skeletal muscles. |
| HTC | 2922499990 |
| PubChem ID | 458834 |
| SMILES | NCC(CC(=O)O)c1ccc(Cl)cc1 |
| InChI | InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
| InChI Key | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.Target: GABA ReceptorBaclofen, a lipophilic analog of gamma-aminobutyric acid, is clinically used to control spasticity. Baclofen pretreatment (3 mg/kg) not only prolonged the time taken for animals to reach a core body temperature of 40 degrees C (P < 0.001), but also reduced the percentage of rats attaining a core body temperature of 40 degrees C [1]. Baclofen overdose may result in coma, apnea, autonomic disturbances, cardiac conduction abnormalities, and seizures. Levels obtained shortly after overdose correlate with length of mechanical ventilation [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74(1): p. 89-96. [2]. Perry, H.E., et al., Baclofen overdose: drug experimentation in a group of adolescents. Pediatrics, 1998. 101(6): p. 1045-8. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 364.3±32.0 °C at 760 mmHg Melting Point 208-210°C Molecular Formula C10H12ClNO2 Molecular Weight 213.661 Flash Point 174.1±25.1 °C Exact Mass 213.055649 PSA 63.32000 LogP 1.56 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.577 InChIKey KPYSYYIEGFHWSV-UHFFFAOYSA-N SMILES NCC(CC(=O)O)c1ccc(Cl)cc1 Water Solubility 1 M HCl: 50 mg/mL |
| Use of | Properties Articles123 Name baclofen Synonym More Synonyms Baclofen Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease References [1]. Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74(1): p. 89-96. [2]. Perry, H.E., et al., Baclofen overdose: drug experimentation in a group of adolescents. Pediatrics, 1998. 101(6): p. 1045-8. Chemical & Physical Properties Exact Mass 213.055649 PSA 63.32000 Index of Refraction 1.577 InChIKey KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 2811 Proper Shipping Name: Toxic Solid, Organic, Not Otherwise Specified Packing grade: III |
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